{"id":"W1774590633","doi":"10.1016/j.cbi.2015.09.020","title":"Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells","year":2015,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Acadia University; Dalhousie University; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Nova Scotia Health Research Foundation","keywords":"Downregulation and upregulation; Cancer research; Cell growth; Cyclin-dependent kinase 1; Biology; PI3K/AKT/mTOR pathway; RHOB; Protein kinase B; Cell cycle; Kinase; Cell biology; RHOA; Signal transduction; Molecular biology; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002350273,0.0003542836,0.0003842939,0.0001439874,0.00008284549,0.00004162001,0.0004287582,0.0004309673,0.00002332456],"category_scores_gemma":[0.0002736022,0.0003192747,0.0001691623,0.0002933646,0.0002054309,0.00001945243,0.0002514418,0.0004245538,0.00001566477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001699241,"about_ca_system_score_gemma":0.00008821041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004608126,"about_ca_topic_score_gemma":0.0001435017,"domain_scores_codex":[0.9979368,0.00008848361,0.0005900992,0.0007588734,0.0001308936,0.0004948094],"domain_scores_gemma":[0.9990034,0.00006782311,0.0001617364,0.000446091,0.0001287421,0.0001922853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004972787,0.0006833917,0.1434046,0.0000194856,0.00001827189,0.000009321866,0.0001276606,0.0001411321,0.8551804,0.00002205928,0.0002160975,0.0001278775],"study_design_scores_gemma":[0.001568784,0.0001515751,0.001125483,0.00003330166,0.00001142211,0.00001422102,0.0006574403,0.002111112,0.9908938,0.0002426039,0.002781958,0.0004082426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968378,0.001063039,0.0005512448,0.00004136415,0.0002592226,0.000278927,0.00003720158,0.00003616351,0.000895036],"genre_scores_gemma":[0.9979849,0.0001331233,0.0005209683,0.0001174151,0.0002321836,0.0001643764,0.0006498588,0.00003188105,0.0001652892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1422791,"threshold_uncertainty_score":0.9999259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06785825949751914,"score_gpt":0.2742985885719193,"score_spread":0.2064403290744002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}