{"id":"W1775279835","doi":"10.1038/ng.3379","title":"Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases","year":2015,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":205,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland; Toronto Western Hospital; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Alfried Krupp von Bohlen und Halbach-Stiftung; Deutsche Forschungsgemeinschaft; National Institute of Allergy and Infectious Diseases; European Commission; Instituto de Salud Carlos III; National Institute for Health and Care Research","keywords":"Rheumatoid arthritis; Autoimmune disease; Allele; Immunology; Psoriasis; Disease; Human leukocyte antigen; Type 1 diabetes; Autoimmunity; Biology; Dominance (genetics); Diabetes mellitus; Genetics; Medicine; Internal medicine; Antigen; Antibody; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007449104,0.000426607,0.0004857539,0.0007945275,0.000256777,0.000802688,0.0004082414,0.0006559217,0.002607542],"category_scores_gemma":[0.001751997,0.0003605184,0.0004376245,0.0006404818,0.0004254719,0.0003076392,0.0005831259,0.000715118,0.000311962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001386275,"about_ca_system_score_gemma":0.0001557395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003903766,"about_ca_topic_score_gemma":0.000554324,"domain_scores_codex":[0.9986843,0.0006002583,0.00007901237,0.0002780845,0.0002000385,0.000158208],"domain_scores_gemma":[0.9980201,0.0008474711,0.0005263269,0.000292594,0.0001006915,0.0002129304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003375778,0.0003492882,0.5123159,0.0001194038,0.00162479,0.001570479,0.0003428785,0.001424242,0.4495884,0.002113412,0.0004067234,0.02676868],"study_design_scores_gemma":[0.00005864127,0.0003919522,0.9830893,0.00001399104,0.0005812793,0.001518742,0.0001588279,0.002403179,0.009525132,0.00164512,0.0005902367,0.00002367971],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971086,0.0006357661,0.00136348,0.00007746537,0.00001444673,0.000003451938,0.00008487776,0.00002524829,0.0006865324],"genre_scores_gemma":[0.9989737,0.0001373175,0.0005222056,0.00002841719,0.00002159657,0.000002942265,0.00003470635,0.00001097444,0.0002680617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002607542,"threshold_uncertainty_score":0.00872314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005562865132505694,"score_gpt":0.2352174815069837,"score_spread":0.229654616374478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}