{"id":"W177600581","doi":"10.69645/ivpt3010","title":"Phase I study design for non-cytotoxic agents","year":2009,"lang":"en","type":"article","venue":"˜The œbiomedical & life sciences collection.","topic":"Animal testing and alternatives","field":"Veterinary","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Cytotoxic T cell; Phase (matter); Chemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001630307,0.0001728067,0.0002065,0.0001805062,0.001657327,0.0001134602,0.000623162,0.00005193846,0.000136952],"category_scores_gemma":[0.0004692066,0.0001111631,0.00008966929,0.001450339,0.0005341575,0.0001510148,0.00005659595,0.0001569101,0.00006553978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000057992,"about_ca_system_score_gemma":0.0002566893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004480841,"about_ca_topic_score_gemma":0.000003464036,"domain_scores_codex":[0.9979181,0.0001991162,0.0003389476,0.000484243,0.0006411407,0.0004183999],"domain_scores_gemma":[0.9987875,0.0005928394,0.0001326172,0.0001838871,0.00007185714,0.0002312908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.007226586,0.03951663,0.003546405,0.00007305812,0.0005297528,0.0004035927,0.01839749,0.000361497,0.05086568,0.0004813584,0.790765,0.08783299],"study_design_scores_gemma":[0.02248161,0.2947817,0.03235814,0.0001956675,0.0002587292,0.0003839293,0.01218757,0.5831835,0.0006966662,0.01126026,0.04056952,0.00164271],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9003497,0.0000774807,0.09272762,0.001478421,0.0009680494,0.001919392,0.00001346986,0.0002336365,0.002232215],"genre_scores_gemma":[0.9935885,0.000004220241,0.002933298,0.0007610038,0.0005028023,0.0001270604,0.000001941588,0.000009142533,0.002072052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7501954,"threshold_uncertainty_score":0.9996424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2186106960264069,"score_gpt":0.4430272663188687,"score_spread":0.2244165702924618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}