{"id":"W1776559329","doi":"10.1039/c5cc05571g","title":"Jadomycins, put a bigger ring in it: isolation of seven- to ten-membered ring analogues","year":2015,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Ring (chemistry); Scope (computer science); Natural product; Chemistry; Stereochemistry; Isolation (microbiology); Biosynthesis; Combinatorial chemistry; Enzyme; Biology; Biochemistry; Bioinformatics; Organic chemistry; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002736092,0.00009167496,0.000235224,0.0001298188,0.00003284445,0.000009292304,0.0003060295,0.00008609221,0.00001334751],"category_scores_gemma":[0.0009322385,0.00007833114,0.00004944541,0.0004672426,0.00007241833,0.00006741537,0.0002761337,0.0002419184,0.00002440054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001014313,"about_ca_system_score_gemma":0.00005167837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002110869,"about_ca_topic_score_gemma":0.00009893641,"domain_scores_codex":[0.9992091,0.00004324704,0.0003311593,0.0001599357,0.0001132154,0.0001433442],"domain_scores_gemma":[0.9986275,0.0001105763,0.00007230271,0.000880311,0.0001841714,0.0001251428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000605577,0.0001788561,0.002294304,0.00003837935,0.00001830361,6.783889e-7,0.0008233383,0.00000667974,0.9925761,0.0001245951,0.001585256,0.002293006],"study_design_scores_gemma":[0.001309036,0.00008024657,0.005907468,0.0006496984,0.00008810728,0.00002353959,0.0007163151,0.002293581,0.9681825,0.0003491726,0.02011846,0.0002818714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742825,0.0006174149,0.00005396147,0.01841353,0.00002998975,0.0003065122,0.00001144226,0.00003693927,0.006247698],"genre_scores_gemma":[0.9847689,0.0000650133,0.01452747,0.0003450367,0.00004862028,0.000002681597,0.00007033953,0.00001099542,0.0001610081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02439354,"threshold_uncertainty_score":0.3194251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07452055104908019,"score_gpt":0.3227373645839261,"score_spread":0.2482168135348459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}