{"id":"W1781139164","doi":"10.1038/nature15209","title":"Unequal opportunity during class switching","year":2015,"lang":"en","type":"letter","venue":"Nature","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Genetics; Locus (genetics); DNA; Biology; V(D)J recombination; Gene; DNA sequencing; Recombination; Immunoglobulin class switching; Genome; Computational biology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002297115,0.0002650844,0.0005355633,0.0002616904,0.001755219,0.002177659,0.000869921,0.01597387,0.004061298],"category_scores_gemma":[0.01023311,0.0002831657,0.0005501861,0.0002277037,0.002586734,0.001843476,0.001485095,0.0126896,0.001368784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001891848,"about_ca_system_score_gemma":0.0008439742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000667422,"about_ca_topic_score_gemma":0.001317524,"domain_scores_codex":[0.9987431,0.0002973372,0.00007857089,0.0002183728,0.000267239,0.0003953621],"domain_scores_gemma":[0.9962463,0.002339811,0.0002607412,0.0003385124,0.0001523109,0.0006624931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.001870821,0.0001695924,0.00682661,0.0001958075,0.000132512,0.02387289,0.0009060554,0.0007900815,0.01391604,0.1382939,0.6931153,0.1199104],"study_design_scores_gemma":[0.0006288313,0.000333056,0.008536513,0.0001902724,0.00009111355,0.01426371,0.0005031613,0.00242156,0.01051151,0.162849,0.7995911,0.00008017732],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.03180869,0.009275055,0.002665944,0.8807783,0.03669584,0.00004085999,0.0001368799,0.0001482339,0.0384502],"genre_scores_gemma":[0.3317912,0.003791137,0.0008602997,0.5895339,0.0492969,0.00009541211,0.0001151922,0.00007236523,0.02444362],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01597387,"threshold_uncertainty_score":0.01372641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02944067299613241,"score_gpt":0.2415548726620009,"score_spread":0.2121141996658685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}