{"id":"W178163506","doi":"10.1161/circ.124.suppl_21.a9763","title":"Abstract 9763: Discovery of a New Role of Human Resistin in Hepatocyte Low-Density Lipoprotein (LDL) Receptor Suppression Mediated by PCSK9","year":2011,"lang":"en","type":"article","venue":"Circulation","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; PCSK9; LDL receptor; Low-density lipoprotein; Resistin; Hepatocyte; Lipoprotein; Internal medicine; Pharmacology; Endocrinology; Cholesterol; Biochemistry; Adiponectin; Biology; Diabetes mellitus; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001830191,0.000315615,0.000291154,0.0001747083,0.0001081228,0.0003220006,0.0001775358,0.0002709381,0.001756685],"category_scores_gemma":[0.0001186253,0.0001082461,0.000334704,0.0001520822,0.0002075713,0.0001572699,0.0001732196,0.0008112592,0.0007233712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000172927,"about_ca_system_score_gemma":0.0001757814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001227641,"about_ca_topic_score_gemma":0.0001546483,"domain_scores_codex":[0.9999061,0.000012135,0.00001077405,0.00001799375,0.00003481144,0.00001821115],"domain_scores_gemma":[0.9999447,0.000008334885,0.00001364956,0.000006943962,0.000007411574,0.00001896236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003413724,0.00004901121,0.00019686,0.00007876123,0.00001156147,0.0002108158,0.00001319384,0.0000556507,0.9929141,0.0002136343,0.0002779538,0.005636993],"study_design_scores_gemma":[0.0001701648,0.0009588803,0.004103078,0.00001431106,0.00003754193,0.001108813,0.00002134107,0.0006613653,0.9817344,0.0001585762,0.01102291,0.000008683804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743747,0.008298243,0.009046201,0.001233513,0.0003843145,0.0001175614,0.001042817,0.0002726914,0.00522987],"genre_scores_gemma":[0.9779146,0.006348639,0.005521024,0.0003589479,0.0001197224,0.0001059152,0.001644307,0.00005342012,0.007933369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001756685,"threshold_uncertainty_score":0.00587672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01388248230811458,"score_gpt":0.233748396294272,"score_spread":0.2198659139861575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}