{"id":"W1781808900","doi":"","title":"Structural modifications to an N-methyl-D-aspartate receptor antagonist result in large differences in trapping block.","year":2001,"lang":"en","type":"article","venue":"PubMed","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"Trapping; Chemistry; NMDA receptor; Lipophilicity; Antagonist; Block (permutation group theory); Stereochemistry; Kinetics; Biophysics; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003374776,0.0005221492,0.0004372473,0.0001739371,0.0001384393,0.0003098678,0.0004262337,0.0003726119,0.002133975],"category_scores_gemma":[0.0004948183,0.0001845678,0.0003923037,0.0001665711,0.0002276327,0.0002863808,0.0001645624,0.0007203274,0.00088524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002093844,"about_ca_system_score_gemma":0.000199512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003179428,"about_ca_topic_score_gemma":0.0007961808,"domain_scores_codex":[0.9997041,0.00006446146,0.00004136903,0.00006495687,0.00007590839,0.00004918761],"domain_scores_gemma":[0.9997332,0.00007234203,0.00009225478,0.00003823247,0.00003521193,0.0000288753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001829728,0.00008805872,0.0002644926,0.0001011753,0.00005749709,0.00009379829,0.00002131922,0.0001333778,0.9911934,0.00008690706,0.00004832542,0.007728584],"study_design_scores_gemma":[0.00021518,0.01972027,0.01334145,0.00003602609,0.0002497453,0.003477856,0.00009587865,0.0006299363,0.9540911,0.0001313508,0.007979189,0.00003212255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834704,0.006621151,0.003992267,0.0001401581,0.00006895237,0.000183769,0.000233296,0.0001047793,0.005185399],"genre_scores_gemma":[0.9885267,0.003701615,0.005222846,0.00021037,0.00002902648,0.00009735434,0.0004428942,0.00002726686,0.00174191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002133975,"threshold_uncertainty_score":0.007138848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1426934870831573,"score_gpt":0.3512100015278818,"score_spread":0.2085165144447246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}