{"id":"W1783154753","doi":"10.1200/jco.2000.18.12.2385","title":"Phase III Comparative Study of Vinorelbine Combined With Doxorubicin Versus Doxorubicin Alone in Disseminated Metastatic/Recurrent Breast Cancer: National Cancer Institute of Canada Clinical Trials Group Study MA8","year":2000,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; BC Cancer Agency","funders":"","keywords":"Medicine; Vinorelbine; Metastatic breast cancer; Anthracycline; Chemotherapy; Neutropenia; Internal medicine; Doxorubicin; Surgery; Breast cancer; Toxicity; Vinca alkaloid; Cancer; Febrile neutropenia; Gastroenterology; Phases of clinical research; Cyclophosphamide; Vincristine; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.008246344,0.0003594466,0.006177202,0.0002790895,0.00005442718,0.000005574894,0.0002765499,0.0001810355,0.001565651],"category_scores_gemma":[0.0007731511,0.0002357804,0.0003794419,0.0006503667,0.0004437717,0.0001631002,0.00004630644,0.001224996,9.352452e-7],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008820232,"about_ca_system_score_gemma":0.00886884,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.08942299,"about_ca_topic_score_gemma":0.6838276,"domain_scores_codex":[0.987626,0.003083502,0.007438636,0.0004226673,0.00106363,0.0003655777],"domain_scores_gemma":[0.9873012,0.006321248,0.004504314,0.0002075095,0.001178782,0.0004869768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.598758,0.1611089,0.1522698,0.0000529152,0.009406178,0.001386763,0.001496666,0.0008420225,0.0001984165,0.00001877345,0.007735782,0.06672575],"study_design_scores_gemma":[0.4148371,0.2355763,0.3382575,0.000276358,0.005268731,0.00007683507,0.002269843,0.0003599221,0.0001210064,0.00001659621,0.002712897,0.0002270148],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915551,0.0006803738,0.000002894181,0.002183674,0.002812147,0.002159539,0.0002100982,0.000005777463,0.0003904165],"genre_scores_gemma":[0.9977808,0.0008909613,0.0001145538,0.0002618817,0.0006392873,0.0000994739,0.00002875002,0.00001915038,0.0001651591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5944046,"threshold_uncertainty_score":0.999347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.310743133948084,"score_gpt":0.5937902368847396,"score_spread":0.2830471029366556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}