{"id":"W1784535584","doi":"10.1210/en.2015-1304","title":"Heme Oxygenase-1 Induction Prevents Autoimmune Diabetes in Association With Pancreatic Recruitment of M2-Like Macrophages, Mesenchymal Cells, and Fibrocytes","year":2015,"lang":"en","type":"article","venue":"Endocrinology","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Health Canada; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"COPP; Mesenchymal stem cell; Vimentin; Heme oxygenase; Downregulation and upregulation; Biology; Internal medicine; CD68; Endocrinology; Pancreas; CD163; Cancer research; Cell biology; Macrophage; Medicine; Immunology; Immunohistochemistry; Heme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000182881,0.0004518513,0.0003868498,0.000408362,0.0001407346,0.0002525616,0.0002486816,0.0003373888,0.001066879],"category_scores_gemma":[0.0001196536,0.0001566541,0.0002196874,0.0001513225,0.0002881187,0.0001893787,0.0001813716,0.0007821807,0.0002376285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00020037,"about_ca_system_score_gemma":0.0002097528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003735956,"about_ca_topic_score_gemma":0.0006525154,"domain_scores_codex":[0.9997911,0.00003612707,0.00001661546,0.00004645834,0.00003604465,0.00007379825],"domain_scores_gemma":[0.9997213,0.00002300688,0.0000997524,0.00002678128,0.00001778497,0.0001113541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006150463,0.000237789,0.0002205419,0.0000415419,0.000005921699,0.00003023849,0.0000134493,0.00002820812,0.9972269,0.00003482747,0.00003437615,0.001511122],"study_design_scores_gemma":[0.00008668775,0.003359408,0.008138289,0.00001315553,0.00003213086,0.0001848295,0.00003103346,0.0004664549,0.9867204,0.00004881499,0.000914209,0.000004463024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981982,0.0005728232,0.0006150383,0.00005369111,0.00001345522,0.00001780545,0.0001017737,0.00005368691,0.0003735727],"genre_scores_gemma":[0.9960786,0.0004809842,0.0009587115,0.00004739797,0.00001822438,0.00004393154,0.0003333002,0.0000232936,0.002015587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001066879,"threshold_uncertainty_score":0.003569126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02012871036895972,"score_gpt":0.2454559569135985,"score_spread":0.2253272465446388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}