{"id":"W1786380341","doi":"10.1038/sj.bjp.0707189","title":"Methyl succinate antagonises biguanide‐induced AMPK‐activation and death of pancreatic <i>β</i>‐cells through restoration of mitochondrial electron transfer","year":2007,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Vlaamse regering; Fonds Wetenschappelijk Onderzoek","keywords":"AMPK; Biguanide; Metformin; Phenformin; AMP-activated protein kinase; Mitochondrion; Protein kinase A; Cell biology; Beta cell; Chemistry; Biology; Phosphorylation; Pharmacology; Biochemistry; Endocrinology; Insulin; Islet","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":{"n_in":0,"stratum":"fund_new","weight":1678.9,"opus":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Pharmacology experiment on biguanide-induced AMPK activation in beta-cells; the object is cell metabolism."},"gpt":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"The study investigates metformin effects on pancreatic beta cells."},"grok":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Biomedical pharmacology of biguanides on pancreatic beta cells."}}}