{"id":"W1787633345","doi":"10.1007/978-3-540-68976-8_4","title":"Bone Marrow-Derived Cells: The Influence of Aging and Cellular Senescence","year":2007,"lang":"en","type":"review","venue":"Handbook of experimental pharmacology","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"","keywords":"Senescence; Stem cell theory of aging; Stem cell; Cell biology; Bone marrow; Telomere; Biology; Progenitor cell; Haematopoiesis; Mesenchymal stem cell; Stromal cell; Telomerase; Adult stem cell; Regeneration (biology); Cancer research; Immunology; Endothelial stem cell; Stem cell factor; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007761025,0.001559924,0.002787692,0.002891941,0.0003504633,0.001362648,0.001553976,0.001498933,0.003367344],"category_scores_gemma":[0.0006503224,0.0005107818,0.0005157558,0.003503505,0.001308416,0.00206367,0.0008186108,0.00326633,0.004398872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008185538,"about_ca_system_score_gemma":0.001083547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001052067,"about_ca_topic_score_gemma":0.002191042,"domain_scores_codex":[0.9997548,0.00002924641,0.00003608128,0.00004213419,0.0001195614,0.00001812093],"domain_scores_gemma":[0.9995783,0.0002191051,0.00004297222,0.00001791912,0.0001042845,0.0000373804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001094759,0.0001180302,0.000144167,0.009865347,0.0000649713,0.0002094727,0.00006206224,0.0003492455,0.005706802,0.007575236,0.04331624,0.932479],"study_design_scores_gemma":[0.00002227664,0.00007339876,0.0005234452,0.001160398,0.00005324186,0.0009205702,0.0000387874,0.0000707187,0.001135917,0.00328567,0.9926934,0.0000221013],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005198087,0.9982647,0.0003076728,0.0001496065,0.0003893861,0.000003946003,0.00001765463,0.000009810868,0.0008051792],"genre_scores_gemma":[0.0003435109,0.9976229,0.0004373252,0.0002303689,0.0003679113,0.000009695307,0.0000347976,0.000003044741,0.0009502897],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003367344,"threshold_uncertainty_score":0.01126486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07139417123535749,"score_gpt":0.4135516569608173,"score_spread":0.3421574857254598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}