{"id":"W1787732800","doi":"10.1159/000438923","title":"The Effect of Aβ<sub>1-42</sub> Oligomers on APP Processing and Aβ<sub>1-40</sub> Generation in Cultured U-373 Astrocytes","year":2015,"lang":"en","type":"article","venue":"Neurodegenerative Diseases","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Alberta; Alberta Innovates - Health Solutions; Alzheimer Society","keywords":"Amyloid precursor protein; Amyloid precursor protein secretase; Chemistry; Molecular biology; Alzheimer's disease; Biology; Internal medicine; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001894578,0.0003265454,0.0004304202,0.0001836029,0.0002403925,0.0003724859,0.0002012159,0.0003878881,0.001149372],"category_scores_gemma":[0.0001298841,0.0002134518,0.0005934284,0.000320979,0.0003088099,0.000310636,0.0001697889,0.0009080873,0.0005853623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003122262,"about_ca_system_score_gemma":0.0005010007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004311481,"about_ca_topic_score_gemma":0.004857019,"domain_scores_codex":[0.999743,0.00004630916,0.00005727641,0.00003933635,0.00004304924,0.00007091815],"domain_scores_gemma":[0.9998651,0.00002749295,0.00002404587,0.00001712134,0.00002573882,0.00004045286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001697271,0.000359547,0.0005236714,0.0001424254,0.00002219654,0.000313199,0.0001780145,0.0001041288,0.9943932,0.0001084761,0.000171185,0.001986725],"study_design_scores_gemma":[0.0001068383,0.002708062,0.01264239,0.00001891378,0.00006609722,0.0002762724,0.0002453845,0.000603168,0.9806294,0.00008727055,0.002599786,0.00001652344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958513,0.001244209,0.0003371003,0.0001095002,0.00005665267,0.00003316214,0.0004549666,0.00002432422,0.00188886],"genre_scores_gemma":[0.9910814,0.00213023,0.001760524,0.0002030867,0.00003059365,0.0001184304,0.000673294,0.00001912155,0.003983336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004311481,"threshold_uncertainty_score":0.008572757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02285240265370215,"score_gpt":0.2948498765788921,"score_spread":0.27199747392519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}