{"id":"W1787732800","doi":"10.1159/000438923","title":"The Effect of Aβ<sub>1-42</sub> Oligomers on APP Processing and Aβ<sub>1-40</sub> Generation in Cultured U-373 Astrocytes","year":2015,"lang":"en","type":"article","venue":"Neurodegenerative Diseases","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Alberta; Alberta Innovates - Health Solutions; Alzheimer Society","keywords":"Amyloid precursor protein; Amyloid precursor protein secretase; Chemistry; Molecular biology; Alzheimer's disease; Biology; Internal medicine; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005667279,0.001181896,0.00131295,0.0004996593,0.0008076406,0.0003563867,0.0004209233,0.0002775289,0.0000215286],"category_scores_gemma":[0.001319322,0.0008235886,0.0004394227,0.0010098,0.0007968099,0.0006724223,0.0002489381,0.0005443138,0.00008035661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004002747,"about_ca_system_score_gemma":0.0009298807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001747806,"about_ca_topic_score_gemma":0.0001949874,"domain_scores_codex":[0.9925891,0.001368171,0.0009948787,0.001619981,0.002066318,0.001361609],"domain_scores_gemma":[0.9955759,0.0005158366,0.000514664,0.0009369215,0.0008360087,0.00162068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01894074,0.004398219,0.04956775,0.00118677,0.00483045,0.001216596,0.001850717,0.002253272,0.8438746,0.0005007244,0.02345458,0.0479256],"study_design_scores_gemma":[0.01473999,0.006679656,0.05491588,0.0006629393,0.002334865,0.0000571638,0.0002490917,0.008628458,0.90922,0.00008895756,0.001239753,0.001183295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9561896,0.03901809,0.0000507931,0.0005135093,0.0003076812,0.00277098,0.0005057316,0.0001866858,0.0004569163],"genre_scores_gemma":[0.9943092,0.002137769,0.00009720384,0.0003089275,0.0008778194,0.0008544186,0.001133473,0.0001793481,0.0001018499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06534538,"threshold_uncertainty_score":0.9994215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02285240265370215,"score_gpt":0.2948498765788921,"score_spread":0.27199747392519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}