{"id":"W1788100462","doi":"10.1158/1538-7445.am2015-lb-129","title":"Abstract LB-129: Identifying tumor subpopulations and the functional consequences of intratumor heterogeneity using single-cell profiling of breast cancer patient-derived xenografts","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biology; Breast cancer; Exome; Cancer research; Exome sequencing; Population; Cancer; Gene; Genetics; Phenotype; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288549,0.0001420194,0.0002467042,0.0002506643,0.0001374132,0.000317569,0.0001395625,0.000207642,0.0009975106],"category_scores_gemma":[0.0001483803,0.00008255044,0.0001377601,0.0001739802,0.0001193619,0.0001079994,0.0001566697,0.0004043668,0.0003973284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001402293,"about_ca_system_score_gemma":0.00009905332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005156993,"about_ca_topic_score_gemma":0.0005825915,"domain_scores_codex":[0.9998775,0.00001680827,0.000008747151,0.00003766585,0.00003986841,0.00001955667],"domain_scores_gemma":[0.9998831,0.00003362822,0.0000195651,0.0000183333,0.00002060427,0.00002479951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001234423,0.00003326669,0.003599417,0.00001366459,0.000005363547,0.0001008947,0.00002224783,0.0001228823,0.9942111,0.00003054683,0.00007722096,0.001659959],"study_design_scores_gemma":[0.00001654641,0.0007558388,0.07269894,0.000007865658,0.00003392044,0.00268396,0.0001020219,0.007096228,0.9134254,0.0001115506,0.003057421,0.00001018078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922464,0.000292229,0.005165476,0.00005074901,0.000007816024,0.00004955771,0.001369723,0.0001284022,0.0006896463],"genre_scores_gemma":[0.9908133,0.0001384826,0.005597961,0.00004020732,0.000003850944,0.00005402943,0.002285249,0.00003721309,0.001029701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009975106,"threshold_uncertainty_score":0.003337026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1364423829722075,"score_gpt":0.3690114640001098,"score_spread":0.2325690810279022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}