{"id":"W1788877136","doi":"10.3233/jad-141902","title":"Alzheimer Amyloid Peptide Aβ42 Regulates Gene Expression of Transcription and Growth Factors","year":2015,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; Douglas Mental Health University Institute; McGill University","funders":"Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Biology; Transcription factor; Gene expression profiling; Microarray analysis techniques; Gene expression; Gene; Senile plaques; Amyloid precursor protein; Alzheimer's disease; Molecular biology; Cell biology; Internal medicine; Genetics; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003048817,0.000296284,0.0005966682,0.0003342511,0.0000730754,0.00003158717,0.0001334178,0.00009134533,0.00009114487],"category_scores_gemma":[0.0001444091,0.0002082191,0.0003634108,0.0001973129,0.0002211401,0.0005177938,0.00004690197,0.0002322696,0.000009863472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004126697,"about_ca_system_score_gemma":0.0005672223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003630337,"about_ca_topic_score_gemma":5.605154e-7,"domain_scores_codex":[0.9975189,0.0001414011,0.0006799405,0.0002607681,0.001046786,0.000352226],"domain_scores_gemma":[0.9961573,0.00005558642,0.000417554,0.0002973848,0.0007783222,0.002293802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01945881,0.00591456,0.8500214,0.0002960619,0.04355714,0.002315772,0.00218154,0.0000442243,0.06024637,0.0001391316,0.01218903,0.003635997],"study_design_scores_gemma":[0.008376769,0.001548335,0.6757587,0.0005199041,0.01706413,0.0001711685,0.0005214035,0.00006160678,0.294136,0.00131456,0.0001719868,0.0003554424],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8890817,0.1097758,0.00002810966,0.0004257714,0.0001348777,0.0003358993,0.00006123349,0.00001928444,0.0001373905],"genre_scores_gemma":[0.997878,0.0008043779,0.0009387268,0.00006632396,0.0001979464,0.000006385977,0.00005050291,0.00004378154,0.00001398572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2338897,"threshold_uncertainty_score":0.8490927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0564278268633044,"score_gpt":0.3090267542198566,"score_spread":0.2525989273565522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}