{"id":"W1788877136","doi":"10.3233/jad-141902","title":"Alzheimer Amyloid Peptide Aβ42 Regulates Gene Expression of Transcription and Growth Factors","year":2015,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; Douglas Mental Health University Institute; McGill University","funders":"Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Biology; Transcription factor; Gene expression profiling; Microarray analysis techniques; Gene expression; Gene; Senile plaques; Amyloid precursor protein; Alzheimer's disease; Molecular biology; Cell biology; Internal medicine; Genetics; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001131684,0.0003633621,0.0002082239,0.0003279355,0.0002323166,0.0004149592,0.00008752395,0.0001837893,0.001331424],"category_scores_gemma":[0.0001300708,0.0001410874,0.0003041954,0.0002878829,0.0001823162,0.0001312093,0.0001728978,0.0002740303,0.0006432584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000377831,"about_ca_system_score_gemma":0.0002748443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003163104,"about_ca_topic_score_gemma":0.002328868,"domain_scores_codex":[0.9998263,0.00001813512,0.000008865383,0.00006549039,0.00004661397,0.0000347411],"domain_scores_gemma":[0.9999106,0.00001879941,0.00001835821,0.000005928735,0.000030715,0.00001560971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001452131,0.00002872981,0.001437186,0.00007716726,0.000009277516,0.00006056586,0.00006536016,0.00007885474,0.9938437,0.0001377741,0.000325249,0.003790931],"study_design_scores_gemma":[0.0000554156,0.0004993558,0.3117761,0.00008896781,0.00009055805,0.0005664384,0.0005631326,0.004459207,0.6567,0.0008081872,0.02435154,0.00004112282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9582521,0.01881631,0.007979891,0.0003222166,0.0001890598,0.0000845273,0.004741443,0.0003419755,0.009272527],"genre_scores_gemma":[0.9733709,0.008001603,0.005271056,0.0003514005,0.00005416436,0.0001210576,0.003047571,0.00005752025,0.009724651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003163104,"threshold_uncertainty_score":0.006289363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0564278268633044,"score_gpt":0.3090267542198566,"score_spread":0.2525989273565522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}