{"id":"W1789647333","doi":"10.1093/nar/gkv497","title":"Spring loading a pre-cleavage intermediate for hairpin telomere formation","year":2015,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Biology; Telomere; Cleavage (geology); DNA; Tn3 transposon; Mutant; Cleavage factor; Telomere-binding protein; Biochemistry; DNA-binding protein; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008402037,0.0001052181,0.0001014078,0.000112205,0.00009719649,0.00006078278,0.000253298,0.0001201331,0.000007142062],"category_scores_gemma":[0.0003875382,0.0001053961,0.00005763043,0.0001241874,0.00006038572,0.00001118499,0.0002145054,0.0001625565,0.00003568943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005137022,"about_ca_system_score_gemma":0.0000600268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002293446,"about_ca_topic_score_gemma":0.00003193192,"domain_scores_codex":[0.998841,0.00004565951,0.0001704627,0.0002501959,0.0002596562,0.000433016],"domain_scores_gemma":[0.9993084,0.00002299111,0.00002424097,0.0002944824,0.0001791888,0.0001706672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003560267,0.00006113538,0.002910745,0.0002184867,0.00005208821,0.000005014898,0.00117931,0.000544852,0.9353001,0.0003919689,0.02427891,0.03470141],"study_design_scores_gemma":[0.001517498,0.0008712332,0.004075594,0.00006880763,0.000009104005,0.00001604666,0.0009402292,0.01130579,0.8346189,0.0004453188,0.1458161,0.0003154192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9492068,0.0008060181,0.04517055,0.0001307237,0.0001942622,0.0004997881,0.00001137519,0.00003417513,0.00394626],"genre_scores_gemma":[0.9962223,0.00006213359,0.002467313,0.00002752118,0.0003684616,0.00007766151,0.00002877105,0.00003351011,0.0007123788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1215372,"threshold_uncertainty_score":0.4297927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04574419006803774,"score_gpt":0.3865079808129965,"score_spread":0.3407637907449587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}