{"id":"W1789647333","doi":"10.1093/nar/gkv497","title":"Spring loading a pre-cleavage intermediate for hairpin telomere formation","year":2015,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Biology; Telomere; Cleavage (geology); DNA; Tn3 transposon; Mutant; Cleavage factor; Telomere-binding protein; Biochemistry; DNA-binding protein; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000179756,0.0002837529,0.0002357851,0.0001435418,0.0002877369,0.0005202236,0.0002805424,0.0004280363,0.001851969],"category_scores_gemma":[0.0003008156,0.0002833309,0.0003524857,0.00007041632,0.0002403168,0.0002776614,0.0004055023,0.0006187577,0.001010914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000422772,"about_ca_system_score_gemma":0.0002703889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003999307,"about_ca_topic_score_gemma":0.0007237525,"domain_scores_codex":[0.9998179,0.00001758518,0.00001716867,0.00004179156,0.00006217163,0.00004331212],"domain_scores_gemma":[0.9997864,0.00003316529,0.00005181167,0.00005558538,0.00002211169,0.00005081254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002280816,0.00001067061,0.0001370459,0.00000815818,0.000001552624,0.00005084184,0.000009837041,0.00004658271,0.9990434,0.0001577119,0.00002127684,0.0004900658],"study_design_scores_gemma":[0.000003866519,0.00004953186,0.0007859222,0.000001745085,0.000002691856,0.0001354585,0.000007922105,0.0005268487,0.9975728,0.00005529395,0.0008549344,0.000002805106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851089,0.000292543,0.01212448,0.000090658,0.0000491578,0.00003082472,0.0001419458,0.000342346,0.001819104],"genre_scores_gemma":[0.9919119,0.00007890115,0.005244554,0.00002556225,0.000004314005,0.00001093172,0.0002428038,0.00005571442,0.002425324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001851969,"threshold_uncertainty_score":0.006195486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04574419006803774,"score_gpt":0.3865079808129965,"score_spread":0.3407637907449587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}