{"id":"W1789945456","doi":"10.3233/jad-2010-1254","title":"Quantitative Changes in the Mitochondrial Proteome from Subjects with Mild Cognitive Impairment, Early Stage, and Late Stage Alzheimer's Disease","year":2010,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institute for Theoretical Astrophysics; National Institute on Aging; University of Kentucky","keywords":"Pathogenesis; Mitochondrion; Alzheimer's disease; Disease; Voltage-dependent anion channel; Proteome; Biology; Tandem mass tag; Dementia; Internal medicine; Bioinformatics; Medicine; Proteomics; Pathology; Biochemistry; Quantitative proteomics; Bacterial outer membrane","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002344886,0.0002539657,0.0002562856,0.0001186785,0.0001025868,0.0000788919,0.0002068112,0.0001069565,0.0001259619],"category_scores_gemma":[0.0001559667,0.0001678587,0.0001142153,0.000122116,0.0002347303,0.00002980106,0.00006002546,0.0004047642,0.000006482392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003635558,"about_ca_system_score_gemma":0.0002540572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007529532,"about_ca_topic_score_gemma":0.0004527371,"domain_scores_codex":[0.9984751,0.0003056053,0.0003071863,0.0003441839,0.0002941118,0.0002738478],"domain_scores_gemma":[0.9986519,0.00007859674,0.0003594746,0.0002679108,0.0002066504,0.0004354838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1255684,0.002962107,0.2747271,0.00008959547,0.004887549,0.003745253,0.005622173,0.0001503482,0.5773636,0.0003547041,0.002694755,0.001834375],"study_design_scores_gemma":[0.01126862,0.005694117,0.9332677,0.0001913353,0.002823823,0.0000308218,0.001372302,0.00007467571,0.03893463,0.0003202776,0.005171993,0.0008496901],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932861,0.004037326,0.0001289132,0.0007127033,0.0005797768,0.0007586603,0.0004478114,0.000005508788,0.00004319721],"genre_scores_gemma":[0.9972321,0.0002026634,0.000853444,0.0007297067,0.0007228189,0.00006091393,0.00009424327,0.00003103754,0.00007306392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6585406,"threshold_uncertainty_score":0.684508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02402344526591762,"score_gpt":0.284206265725147,"score_spread":0.2601828204592294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}