{"id":"W1790693342","doi":"10.1002/bip.22250","title":"Peptide design for antimicrobial and immunomodulatory applications","year":2013,"lang":"en","type":"review","venue":"Biopolymers","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":289,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canada Research Chairs; Foundation for the National Institutes of Health","keywords":"Antimicrobial peptides; Antibiotics; Antimicrobial; Antibacterial peptide; Peptide; Innate immune system; Chemistry; Antibiotic resistance; Computational biology; Pathogenic bacteria; Immune system; Microbiology; Biology; Bacteria; Antibacterial activity; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000142504,0.0005250659,0.001277132,0.0001970778,0.0003827336,0.00006440518,0.0003128639,0.0006810802,0.0001765625],"category_scores_gemma":[0.00001307392,0.0004430477,0.0004574965,0.0001069886,0.000574544,0.000109747,0.000122334,0.0003005753,0.000521365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005277452,"about_ca_system_score_gemma":0.0002010115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007763645,"about_ca_topic_score_gemma":0.000001080911,"domain_scores_codex":[0.9982784,0.0001325066,0.0004952117,0.0005768767,0.00001888333,0.0004981492],"domain_scores_gemma":[0.998883,0.0002973459,0.000363505,0.0003792499,0.0000413097,0.0000355679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001559899,0.00006003476,3.070978e-7,0.00368467,0.0006003899,4.886517e-7,0.00003398248,1.4393e-7,0.009458566,0.0005095073,0.03649532,0.949141],"study_design_scores_gemma":[0.0003059381,0.00005339076,2.947917e-7,0.001056651,0.0006016663,0.00009758178,0.00004520212,2.207466e-7,0.002696113,0.00001675822,0.9946185,0.0005076986],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00000820538,0.9924695,0.003601417,0.00002221729,0.0004694703,0.00273528,0.0004032658,0.00009532568,0.0001953143],"genre_scores_gemma":[0.00002725018,0.9884001,0.001390532,0.00007387163,0.0001373029,0.0009141244,0.0005974346,0.00009226377,0.008367117],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9581231,"threshold_uncertainty_score":0.9998021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04335603115096608,"score_gpt":0.2860048028457169,"score_spread":0.2426487716947508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}