{"id":"W1790693342","doi":"10.1002/bip.22250","title":"Peptide design for antimicrobial and immunomodulatory applications","year":2013,"lang":"en","type":"review","venue":"Biopolymers","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":289,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canada Research Chairs; Foundation for the National Institutes of Health","keywords":"Antimicrobial peptides; Antibiotics; Antimicrobial; Antibacterial peptide; Peptide; Innate immune system; Chemistry; Antibiotic resistance; Computational biology; Pathogenic bacteria; Immune system; Microbiology; Biology; Bacteria; Antibacterial activity; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003962445,0.000985941,0.0009015966,0.001251254,0.0002564215,0.0007787796,0.0005325789,0.001144059,0.002472884],"category_scores_gemma":[0.000312048,0.0003696732,0.0004386072,0.001274544,0.0003898805,0.001032896,0.0006270996,0.00178751,0.002131356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004195683,"about_ca_system_score_gemma":0.0004230046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002872687,"about_ca_topic_score_gemma":0.0003541378,"domain_scores_codex":[0.9998118,0.00002734574,0.00001992469,0.00003411798,0.00008149787,0.00002528161],"domain_scores_gemma":[0.999913,0.00002332269,0.00002241352,0.000004531922,0.00002499813,0.00001171574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001312631,0.0002102515,0.0001812938,0.01525604,0.0000765656,0.0008291311,0.0001226697,0.001696786,0.1336205,0.01398859,0.01247732,0.8214096],"study_design_scores_gemma":[0.00004045155,0.0003446957,0.0005548857,0.001431261,0.00005588845,0.001980287,0.00004508971,0.0004833468,0.02397583,0.003103798,0.9679525,0.00003178669],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002797276,0.9867073,0.002777934,0.0002778247,0.0005521121,0.00004033843,0.00005351307,0.00002803709,0.006765606],"genre_scores_gemma":[0.01283313,0.977192,0.004034832,0.0004057368,0.000261197,0.00007431169,0.0001009984,0.000008674435,0.005089223],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002472884,"threshold_uncertainty_score":0.008272588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04335603115096608,"score_gpt":0.2860048028457169,"score_spread":0.2426487716947508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}