{"id":"W1791079802","doi":"10.4049/jimmunol.170.4.1625","title":"Cutting Edge: Distinct Toll-Like Receptor 2 Activators Selectively Induce Different Classes of Mediator Production from Human Mast Cells","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":349,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Degranulation; Zymosan; TLR2; TLR4; Leukotriene C4; Peptidoglycan; Toll-like receptor; Mast cell; Biology; Cell biology; Microbiology; Activator (genetics); Receptor; CD14; Leukotriene; Innate immune system; Immunology; Signal transduction; Biochemistry; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002837445,0.0003633817,0.0002459442,0.0001724331,0.000110715,0.0004584132,0.000137241,0.0005201765,0.004057562],"category_scores_gemma":[0.0002608658,0.000153108,0.0003181163,0.000161746,0.0001240399,0.0003052276,0.0003582947,0.0004865915,0.001364011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001581956,"about_ca_system_score_gemma":0.0001148468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005740982,"about_ca_topic_score_gemma":0.00009770496,"domain_scores_codex":[0.9997632,0.00004301814,0.00003240967,0.00004329422,0.00004762736,0.00007041534],"domain_scores_gemma":[0.9998695,0.00004830521,0.00002133387,0.00001977206,0.00001653014,0.00002454731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000455225,0.000026552,0.0004228018,0.0001308654,0.000004370903,0.0001466607,0.00001500162,0.0000078302,0.9937351,0.00006956269,0.0001999408,0.00478599],"study_design_scores_gemma":[0.0001622959,0.0009155871,0.01783475,0.00003028822,0.0000462302,0.003233567,0.00007422267,0.000207965,0.9692158,0.0001876905,0.008084133,0.000007511716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728371,0.01587881,0.004773607,0.0008377414,0.0002133843,0.0001556569,0.00145063,0.0001252571,0.003727762],"genre_scores_gemma":[0.9841978,0.00397033,0.00476338,0.0006014745,0.0001797558,0.0001199481,0.002469452,0.00002521905,0.003672676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004057562,"threshold_uncertainty_score":0.01357388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159133396656853,"score_gpt":0.2220824378661533,"score_spread":0.2104911038995848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}