{"id":"W1791079802","doi":"10.4049/jimmunol.170.4.1625","title":"Cutting Edge: Distinct Toll-Like Receptor 2 Activators Selectively Induce Different Classes of Mediator Production from Human Mast Cells","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":349,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Degranulation; Zymosan; TLR2; TLR4; Leukotriene C4; Peptidoglycan; Toll-like receptor; Mast cell; Biology; Cell biology; Microbiology; Activator (genetics); Receptor; CD14; Leukotriene; Innate immune system; Immunology; Signal transduction; Biochemistry; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005929178,0.0002495535,0.0006123122,0.0001716829,0.0002950156,0.000008526579,0.000408631,0.0002723476,0.0008678721],"category_scores_gemma":[0.0002854829,0.0001626945,0.0001395492,0.0001700676,0.0004781954,0.0001083465,0.00007514752,0.0008865114,0.00004287963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001139557,"about_ca_system_score_gemma":0.0001218428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008844466,"about_ca_topic_score_gemma":0.00003512329,"domain_scores_codex":[0.9975704,0.0010041,0.000801526,0.0001969874,0.00007856754,0.0003484367],"domain_scores_gemma":[0.9977521,0.0003983678,0.001246587,0.000309924,0.0002668601,0.00002617694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004389436,0.0003202505,0.002261805,0.00001395819,0.0006004346,0.000001854628,0.00121622,0.00000251798,0.9910153,0.0002083584,0.002677538,0.001242865],"study_design_scores_gemma":[0.00112652,0.0006740965,0.01523699,0.00006082284,0.0001679476,0.0001479589,0.001587412,1.409419e-7,0.9540218,0.0002022298,0.02661336,0.0001607202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920308,0.003414655,0.00009033042,0.0002216521,0.00370865,0.0001629813,0.00002006106,0.00002024163,0.000330624],"genre_scores_gemma":[0.9982961,0.0003375006,0.00008540152,0.000021179,0.0001539949,0.000003421603,0.00001485392,0.00003151838,0.001056055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03699346,"threshold_uncertainty_score":0.9502591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159133396656853,"score_gpt":0.2220824378661533,"score_spread":0.2104911038995848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}