{"id":"W1792412328","doi":"10.1128/jvi.01165-15","title":"Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"","keywords":"Tauroursodeoxycholic acid; Neuroprotection; Ursodeoxycholic acid; Biology; Neurodegeneration; Amyotrophic lateral sclerosis; Pharmacology; Disease; Cell biology; Biochemistry; Internal medicine; Medicine; Unfolded protein response; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002015644,0.000731064,0.0006362036,0.0004076897,0.0002408692,0.0002524942,0.0003575135,0.000482221,0.00149673],"category_scores_gemma":[0.0001823809,0.0001215738,0.0002894447,0.0002286653,0.0003354745,0.0003056489,0.000278512,0.0007129058,0.0003551781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002402511,"about_ca_system_score_gemma":0.0003403614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006450895,"about_ca_topic_score_gemma":0.001705778,"domain_scores_codex":[0.9998633,0.00002963984,0.00001697181,0.0000213961,0.00003527096,0.00003342625],"domain_scores_gemma":[0.9997526,0.00001890037,0.00008729548,0.00002459602,0.00004285806,0.00007378879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004310443,0.0005083505,0.001038408,0.0002867382,0.00006412978,0.0001730837,0.00006652639,0.0001111066,0.9827089,0.00009182768,0.0002513396,0.01038923],"study_design_scores_gemma":[0.0001785177,0.007374987,0.009765049,0.00004343928,0.0001153119,0.0003101478,0.0001021852,0.0004150213,0.9777999,0.0001009772,0.003778698,0.00001572897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846647,0.01058569,0.002156726,0.0003981291,0.0001677239,0.00005663562,0.0006107549,0.00024995,0.001109616],"genre_scores_gemma":[0.9833421,0.007806435,0.002633215,0.0001549908,0.00006024908,0.0001225241,0.0007199853,0.00004495554,0.005115595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00149673,"threshold_uncertainty_score":0.005007088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02341335387905499,"score_gpt":0.2700245558462342,"score_spread":0.2466112019671792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}