{"id":"W1792487168","doi":"10.1016/j.freeradbiomed.2015.07.154","title":"NOD2 activation induces oxidative stress contributing to mitochondrial dysfunction and insulin resistance in skeletal muscle cells","year":2015,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Indian Council of Medical Research","keywords":"Skeletal muscle; Insulin receptor; Muramyl dipeptide; Oxidative stress; Insulin resistance; Mitochondrial ROS; Mitochondrion; Tyrosine phosphorylation; Phosphorylation; Cell biology; Protein kinase B; Oxidative phosphorylation; Reactive oxygen species; Biology; Chemistry; Insulin; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003638295,0.0004284439,0.0003676123,0.0002427873,0.0002877418,0.0003707462,0.0002174575,0.0004339177,0.002409777],"category_scores_gemma":[0.0001314695,0.0002453119,0.0005665054,0.0002676484,0.0003301178,0.0003321721,0.0005382877,0.0008693053,0.0003955795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002064943,"about_ca_system_score_gemma":0.0002270003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003376268,"about_ca_topic_score_gemma":0.0006291725,"domain_scores_codex":[0.9997142,0.00006266147,0.00003345175,0.00006211131,0.00005469289,0.00007287238],"domain_scores_gemma":[0.9999125,0.00001047347,0.0000180042,0.00001459037,0.00001251661,0.0000319515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008978041,0.0001040634,0.000656166,0.00006957039,0.00002231163,0.0001834692,0.00002752314,0.00004085891,0.9969502,0.00008531928,0.0001075015,0.0008552552],"study_design_scores_gemma":[0.0003845218,0.002577293,0.04961526,0.00004389663,0.0001425207,0.001615105,0.0006422681,0.002023145,0.9373085,0.0003368788,0.005284819,0.00002569276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962328,0.0009555533,0.001208029,0.0002084569,0.00007715407,0.00002164525,0.0002311594,0.00003453097,0.001030703],"genre_scores_gemma":[0.9956994,0.0004777838,0.0006287968,0.0001347829,0.00002197946,0.00006685669,0.0006129406,0.000008288774,0.002349289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002409777,"threshold_uncertainty_score":0.008061528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02182459599782235,"score_gpt":0.2941894224855113,"score_spread":0.2723648264876889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}