{"id":"W1793796070","doi":"10.1038/ncomms8743","title":"MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":686,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Sahlgrenska Akademin; Science for Life Laboratory; Göteborgs Universitet; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Chalmers Tekniska Högskola; Barncancerfonden; Cancerfonden; Stiftelsen för Strategisk Forskning; Swedish Cancer Foundation","keywords":"RNA; Long non-coding RNA; DNA; Non-coding RNA; Gene; Genetics; Biology; MEG3; Computational biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004333087,0.0001468303,0.0001423077,0.0000576608,0.0002544105,0.0000457359,0.001348557,0.0004061923,0.0000079847],"category_scores_gemma":[0.0002837076,0.0001143312,0.00009832576,0.0002635625,0.0001749256,0.00002726548,0.0005208671,0.0005224684,0.000002680176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005273931,"about_ca_system_score_gemma":0.0002024346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000472039,"about_ca_topic_score_gemma":0.0005404377,"domain_scores_codex":[0.9986889,0.0003117265,0.0002799855,0.0002035872,0.000309224,0.0002065524],"domain_scores_gemma":[0.9970947,0.00004575541,0.0001831443,0.002114048,0.0004864541,0.00007591325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006064475,0.00005257687,0.00000969249,0.00001356146,0.00006332084,5.665813e-7,0.0005223151,0.0004879344,0.9804577,0.008281901,0.002594815,0.007454989],"study_design_scores_gemma":[0.0004483912,0.0001241544,0.0001100199,0.00001643697,0.00002633153,0.00001806064,0.0004420675,0.001128258,0.9426632,0.001798365,0.05308463,0.0001400881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6630399,0.2160099,0.07580142,0.0130197,0.001493738,0.00364707,0.0003982134,0.0002101017,0.02637993],"genre_scores_gemma":[0.991723,0.001662982,0.005502993,0.0002594065,0.0001161306,0.00004514056,0.0005432387,0.00002698444,0.0001201338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.328683,"threshold_uncertainty_score":0.4662291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04074362933151962,"score_gpt":0.3324960084289528,"score_spread":0.2917523790974331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}