{"id":"W1793796070","doi":"10.1038/ncomms8743","title":"MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":686,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Sahlgrenska Akademin; Science for Life Laboratory; Göteborgs Universitet; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Chalmers Tekniska Högskola; Barncancerfonden; Cancerfonden; Stiftelsen för Strategisk Forskning; Swedish Cancer Foundation","keywords":"RNA; Long non-coding RNA; DNA; Non-coding RNA; Gene; Genetics; Biology; MEG3; Computational biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000725136,0.000171027,0.0001329844,0.0001544847,0.0001360496,0.0002001312,0.00007646642,0.0001310967,0.001182685],"category_scores_gemma":[0.00009135555,0.00009251566,0.0002349502,0.0001159559,0.0001433028,0.0001303294,0.000160151,0.0002414783,0.0002949144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001922671,"about_ca_system_score_gemma":0.0001359382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005787647,"about_ca_topic_score_gemma":0.00122246,"domain_scores_codex":[0.9999367,0.000006128619,0.00000335393,0.0000202535,0.00002119006,0.00001237674],"domain_scores_gemma":[0.9999522,0.00001103995,0.00001574808,0.00000361608,0.000007279146,0.00001009699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003160587,0.000002195445,0.0006918701,0.000008251176,0.000002126089,0.00002192129,0.000006349334,0.00002757294,0.9983551,0.00004230353,0.00001634229,0.000794287],"study_design_scores_gemma":[0.0000103652,0.00007271418,0.05632935,0.000004432992,0.0000163929,0.0002163126,0.0000569469,0.001360516,0.9397038,0.0001648407,0.002059308,0.000004991102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927086,0.001143476,0.004096864,0.00008445472,0.00001900691,0.00001113747,0.000506826,0.00009018032,0.001339456],"genre_scores_gemma":[0.9957979,0.0004424457,0.001558949,0.00006862284,0.000006003957,0.00001279684,0.0004715149,0.00001786515,0.001623722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001182685,"threshold_uncertainty_score":0.003956437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04074362933151962,"score_gpt":0.3324960084289528,"score_spread":0.2917523790974331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}