{"id":"W1794184128","doi":"10.1016/s0016-5085(03)01195-8","title":"Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene1 1The authors thank Emmy De Blay and Luc Bouwens for generous assistance with islet immunohistochemistry.","year":2003,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University; Toronto General Hospital; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Gastrin; Internal medicine; Endocrinology; Islet; Glucagon; Glucose homeostasis; Neogenesis; Pancreas; Enteroendocrine cell; Insulin; Hypoglycemia; Biology; Secretion; Medicine; Hormone; Endocrine system; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003478734,0.0002666288,0.0004651246,0.00009534443,0.00009693739,0.00001216294,0.0001034116,0.0001441511,0.00002518569],"category_scores_gemma":[0.0001769278,0.0001870167,0.00008699688,0.0001673608,0.0003533202,0.00005940987,0.00002449815,0.0002733554,0.000001163632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002032515,"about_ca_system_score_gemma":0.0001382378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006974391,"about_ca_topic_score_gemma":0.00005454921,"domain_scores_codex":[0.9983155,0.0002067374,0.0003384056,0.0004060791,0.0001857348,0.0005475744],"domain_scores_gemma":[0.9990226,0.0001077103,0.0002793556,0.0003259266,0.0001478725,0.00011655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006765828,0.000170642,0.4478805,0.0001854338,0.0001640341,0.00001486766,0.0004306393,0.0002078725,0.5438056,0.00006213934,0.0002701707,0.00004224073],"study_design_scores_gemma":[0.03808,0.01183969,0.501414,0.0009548722,0.001460388,0.003510148,0.003359308,0.00142214,0.4357283,0.0004236401,0.001130133,0.0006773547],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792976,0.0001774068,0.01890406,0.0004192765,0.00008002222,0.0006468097,0.00007781776,0.00002333648,0.0003736363],"genre_scores_gemma":[0.9929661,0.00002636865,0.005586736,0.0006369465,0.00006115639,0.0002115683,0.00005420197,0.00003204117,0.0004249079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1080773,"threshold_uncertainty_score":0.7626322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005922270772014277,"score_gpt":0.2213594500263706,"score_spread":0.2154371792543564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}