{"id":"W1794184128","doi":"10.1016/s0016-5085(03)01195-8","title":"Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene1 1The authors thank Emmy De Blay and Luc Bouwens for generous assistance with islet immunohistochemistry.","year":2003,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University; Toronto General Hospital; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Gastrin; Internal medicine; Endocrinology; Islet; Glucagon; Glucose homeostasis; Neogenesis; Pancreas; Enteroendocrine cell; Insulin; Hypoglycemia; Biology; Secretion; Medicine; Hormone; Endocrine system; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004001954,0.001699351,0.0004554533,0.001946748,0.0003335884,0.000719961,0.0005005572,0.001006125,0.004384921],"category_scores_gemma":[0.0003630504,0.0006010334,0.0004304215,0.0004880639,0.001053807,0.0005409286,0.0006598202,0.001791951,0.0007710044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003847912,"about_ca_system_score_gemma":0.0002908483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000316707,"about_ca_topic_score_gemma":0.0007724624,"domain_scores_codex":[0.9995871,0.00004792262,0.00004287173,0.0001453058,0.0001278896,0.00004891728],"domain_scores_gemma":[0.9993312,0.00007360661,0.0002819349,0.00005908341,0.0000181263,0.0002360622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009239338,0.0001247246,0.001310721,0.00009376204,0.00003493895,0.001036125,0.0000730358,0.0002035746,0.9912336,0.0007659173,0.0006012387,0.003598298],"study_design_scores_gemma":[0.001028826,0.002053864,0.09458383,0.0001333033,0.0003305654,0.023881,0.0002502497,0.002553994,0.8528062,0.002537951,0.01973937,0.0001008301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736169,0.003018348,0.008977003,0.0008980457,0.0003329715,0.00006284278,0.005358586,0.0009544443,0.006780884],"genre_scores_gemma":[0.9647495,0.002541918,0.007660073,0.0004937169,0.0001897688,0.0002144172,0.004860451,0.0007452645,0.01854487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004384921,"threshold_uncertainty_score":0.01466906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005922270772014277,"score_gpt":0.2213594500263706,"score_spread":0.2154371792543564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}