{"id":"W1794576454","doi":"10.1210/en.2015-1361","title":"Chronic Exposure to TNFα Impairs Secretion of Glucagon-Like Peptide-1","year":2015,"lang":"en","type":"article","venue":"Endocrinology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Endocrinology; Internal medicine; Proglucagon; Hyperinsulinemia; Glucagon-like peptide-1; Incretin; Tumor necrosis factor alpha; Glucose homeostasis; Secretion; Peptide YY; Glucagon-like peptide-2; Glucose tolerance test; Receptor; Biology; Medicine; Insulin resistance; Insulin; Type 2 diabetes; Diabetes mellitus; Neuropeptide Y receptor; Neuropeptide; Peptide; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002121572,0.000424948,0.0004826325,0.0002631726,0.0001547346,0.0004024927,0.0001723685,0.0003672907,0.001384677],"category_scores_gemma":[0.0001564034,0.0001754084,0.0004075265,0.0002449315,0.0002642273,0.0002550879,0.0001917356,0.000917428,0.0006315479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000253013,"about_ca_system_score_gemma":0.0002683679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005780082,"about_ca_topic_score_gemma":0.0005152723,"domain_scores_codex":[0.9996862,0.0000474866,0.00005549073,0.00004873777,0.00006040616,0.0001016108],"domain_scores_gemma":[0.9997684,0.00002185796,0.00007160014,0.00003186699,0.00002320875,0.00008294079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001714084,0.0002534519,0.0005662457,0.00006632572,0.00001457701,0.00009153334,0.00002814384,0.00005101735,0.9953778,0.00003706555,0.0001072174,0.001692461],"study_design_scores_gemma":[0.0002763019,0.007075666,0.01474931,0.00003609708,0.00007297056,0.0006916816,0.0001982369,0.001117828,0.9716331,0.00008360732,0.004053228,0.00001203817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932703,0.003369807,0.001344622,0.0001830524,0.000190441,0.00002970303,0.0005031141,0.0000824366,0.001026451],"genre_scores_gemma":[0.9945721,0.001776059,0.0007682338,0.0001054379,0.00004731509,0.00005954922,0.0007055333,0.00001100741,0.001954874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001384677,"threshold_uncertainty_score":0.004632175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02277801182278087,"score_gpt":0.276847540529066,"score_spread":0.2540695287062851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}