{"id":"W1795031534","doi":"10.1152/ajpgi.2001.281.2.g323","title":"Protease-activated receptor-1 stimulates Ca<sup>2+</sup>-dependent Cl<sup>−</sup>secretion in human intestinal epithelial cells","year":2001,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Cystic fibrosis transmembrane conductance regulator; Thapsigargin; Secretion; Molecular biology; Thrombin; Protease-activated receptor 2; Receptor; Biology; Apical membrane; DIDS; Intracellular; Internal medicine; Endocrinology; Chemistry; Epithelium; Cell biology; Biochemistry; Cystic fibrosis; Immunology; Medicine; Enzyme-linked receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002263247,0.0003601683,0.0005837749,0.0001910333,0.0001571936,0.0004622467,0.0001599665,0.0003302399,0.002357715],"category_scores_gemma":[0.0002681117,0.0001852939,0.0004618271,0.0002424979,0.0001426684,0.000298015,0.0002520939,0.0005676554,0.001131397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003241904,"about_ca_system_score_gemma":0.0001459153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005791517,"about_ca_topic_score_gemma":0.0006017613,"domain_scores_codex":[0.9997342,0.00005258034,0.00003020607,0.00004692581,0.00008155857,0.00005462033],"domain_scores_gemma":[0.9998859,0.00003131905,0.00002296824,0.00001559011,0.00001761999,0.00002654471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004094901,0.00003734937,0.0002837452,0.0001287263,0.000008147228,0.0001972442,0.00004879813,0.00003636309,0.9968805,0.00003722406,0.000178439,0.001753898],"study_design_scores_gemma":[0.0002438613,0.0012117,0.03195768,0.0000291279,0.00005236482,0.001513674,0.000200714,0.002280674,0.9521763,0.0001373047,0.01017764,0.00001908426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839984,0.00811147,0.002619161,0.0005701553,0.0001182529,0.0001053087,0.001173572,0.0001511438,0.003152547],"genre_scores_gemma":[0.9903451,0.002512636,0.00251741,0.000376731,0.0000884999,0.00008754577,0.001667813,0.000026844,0.002377508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002357715,"threshold_uncertainty_score":0.007887363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01582277396288191,"score_gpt":0.2562558944242457,"score_spread":0.2404331204613638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}