{"id":"W179573588","doi":"10.1038/npre.2009.2867.1","title":"Evolutionary descent of prion genes from a ZIP metal ion transport ancestor","year":2009,"lang":"en","type":"preprint","venue":"Nature Precedings","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Toronto","funders":"","keywords":"Phylogenetic tree; Biology; Prion protein; Gene; Prion Proteins; Fungal prion; Function (biology); Genetics; Phylogenetics; Transmembrane domain; Computational biology; Transmembrane protein; Interactome; Phenotype; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001777279,0.00034583,0.0003726662,0.00007693586,0.00005950841,0.00001506812,0.0004538379,0.001372978,0.00004804026],"category_scores_gemma":[0.00007323334,0.0003426355,0.0004049116,0.00007768227,0.00005946381,0.000006778816,0.0002407414,0.0006986378,0.000001854342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005417474,"about_ca_system_score_gemma":0.0002105168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007331412,"about_ca_topic_score_gemma":0.00001297449,"domain_scores_codex":[0.9982252,0.00005720166,0.0003771234,0.0007449297,0.000341626,0.0002539285],"domain_scores_gemma":[0.9988723,0.00001104157,0.0003409292,0.000458705,0.0001898351,0.00012712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006142497,0.0001702908,0.006017209,0.0002401774,0.0002703469,0.000006687038,0.00007176051,0.0002468469,0.9410154,0.00007643578,0.001475335,0.04979525],"study_design_scores_gemma":[0.0009028601,0.0003128382,0.0651885,0.0007667353,0.0004177756,0.00001052741,0.00002628433,0.0001626714,0.8594006,0.003363844,0.06854371,0.0009036104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8171031,0.1800256,0.0008882232,0.0001740168,0.0007679191,0.0004728997,0.0003519208,0.00003169971,0.0001846448],"genre_scores_gemma":[0.9744205,0.01536524,0.007265877,0.0001557148,0.0009773944,0.00004080561,0.001696752,0.0000328178,0.00004491102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1646603,"threshold_uncertainty_score":0.9999235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008852658585438995,"score_gpt":0.2589825743485283,"score_spread":0.2501299157630893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}