{"id":"W1799341239","doi":"10.1016/j.bbadis.2015.09.017","title":"Bone marrow-derived macrophages and the CNS: An update on the use of experimental chimeric mouse models and bone marrow transplantation in neurological disorders","year":2015,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Microglia; Bone marrow; Chimera (genetics); Neuroscience; Central nervous system; Transplantation; Inflammation; Medicine; Mononuclear phagocyte system; Immunology; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000247556,0.0005955193,0.0009854959,0.0002436568,0.0001324083,0.0001402918,0.0004353417,0.0001253287,0.00001035832],"category_scores_gemma":[0.0001780449,0.0003811272,0.000334049,0.0003912202,0.0006787807,0.0003241559,0.0001585837,0.0003381409,0.000002302191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001211436,"about_ca_system_score_gemma":0.0001081316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007747219,"about_ca_topic_score_gemma":0.000001621211,"domain_scores_codex":[0.995079,0.002334702,0.0007648898,0.0009395526,0.0005963468,0.0002854432],"domain_scores_gemma":[0.9979463,0.0003555823,0.0006426667,0.0007748912,0.00003657755,0.0002439889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001179029,0.0005726424,9.706569e-8,0.0006459474,0.00002504312,0.00004515136,0.0001876736,0.0001053457,0.9894205,0.004300945,0.00002272232,0.003494877],"study_design_scores_gemma":[0.002065137,0.000494549,0.00002518167,0.000372413,0.0005457827,0.00001901291,0.00002211987,0.00439811,0.9904766,0.0005702931,0.0003843129,0.0006264801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9544585,0.04171133,0.00004542498,0.001280265,0.00005744501,0.001857424,0.0005341463,0.00004624049,0.000009275017],"genre_scores_gemma":[0.5642117,0.4344443,0.00007239982,0.0009613885,0.00001222048,0.0001448783,0.00008671879,0.00006060177,0.000005721152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.392733,"threshold_uncertainty_score":0.999864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06037025370503672,"score_gpt":0.2905478663535916,"score_spread":0.2301776126485549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}