{"id":"W1800003803","doi":"10.4049/jimmunol.175.8.5324","title":"<i>Mycobacterium bovis</i> BCG Attenuates Surface Expression of Mature Class II Molecules through IL-10-Dependent Inhibition of Cathepsin S","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health Research Institute; University of British Columbia; Vancouver Coastal Health","funders":"Genentech","keywords":"Biology; MHC class II; Molecular biology; MHC class I; Mycobacterium bovis; Cathepsin S; Secretion; Immune system; T cell; Major histocompatibility complex; Cathepsin B; Immunology; Mycobacterium tuberculosis; Biochemistry; Tuberculosis; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001181826,0.0001652759,0.0007010453,0.0001060555,0.00007867415,0.000003042151,0.0002500601,0.0002471959,0.000210483],"category_scores_gemma":[0.0004682991,0.0000885652,0.0001911711,0.0001349101,0.0003802663,0.0001529837,0.0001783252,0.0007002571,0.00001794294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007946375,"about_ca_system_score_gemma":0.0001232428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008304219,"about_ca_topic_score_gemma":0.00001110754,"domain_scores_codex":[0.9976844,0.0006653829,0.0008803152,0.0001200746,0.0003063456,0.0003434721],"domain_scores_gemma":[0.9979207,0.0003741965,0.0008115198,0.0003699714,0.000460923,0.00006271742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002936183,0.0002909742,0.0005405959,0.00005213575,0.0002036525,0.00001608378,0.0009231066,0.0002170907,0.9832279,0.00006556803,0.01081969,0.0007070338],"study_design_scores_gemma":[0.001886207,0.002209274,0.006428197,0.0003490683,0.0001415612,0.001227228,0.0006718017,0.00003774364,0.9743432,0.0003316489,0.01228542,0.00008867573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726566,0.006972899,0.0001635588,0.01950513,0.0001370709,0.0001531623,0.00002496131,0.000008561733,0.0003780358],"genre_scores_gemma":[0.9912971,0.00639077,0.0012299,0.0005181588,0.0001591985,0.000001289521,0.00001233317,0.0000193037,0.00037196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01898697,"threshold_uncertainty_score":0.3611584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01761303902479781,"score_gpt":0.291594343910969,"score_spread":0.2739813048861712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}