{"id":"W1801209061","doi":"10.1096/fasebj.28.1_supplement.1133.2","title":"Functional recovery of AQP2 recessive mutations through hetero‐oligomerization with wild‐type counterpart (1133.2)","year":2014,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; Université de Montréal","funders":"","keywords":"Aquaporin 2; Nephrogenic diabetes insipidus; Mutant; Homomeric; Reabsorption; Xenopus; Heterozygote advantage; Wild type; Cell biology; Transfection; Mutation; Chemistry; Kidney; Aquaporin; HEK 293 cells; Biology; Gene; Molecular biology; Genetics; Allele; Water channel","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319938,0.0002646768,0.0001712287,0.0001819701,0.0001338875,0.0002539958,0.0001843585,0.0003322972,0.002011807],"category_scores_gemma":[0.0001181358,0.0001058511,0.0002517637,0.0001383829,0.0002389931,0.0001660879,0.000202158,0.0005825487,0.0008147291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001512403,"about_ca_system_score_gemma":0.0001827499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006261091,"about_ca_topic_score_gemma":0.0005894295,"domain_scores_codex":[0.9998857,0.00001584383,0.00001272352,0.00002949073,0.00003048484,0.00002575905],"domain_scores_gemma":[0.9999049,0.00001667579,0.00002903524,0.00001769841,0.000007192972,0.00002447854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002247268,0.000008858011,0.00006996549,0.00001045631,0.000001859189,0.0000748672,0.000006466806,0.00001479128,0.9993179,0.00006125344,0.00002837969,0.0003826152],"study_design_scores_gemma":[0.00001121312,0.0001009714,0.003395149,0.000003745292,0.00001369975,0.001680312,0.00003204849,0.0004813827,0.9911771,0.00004679734,0.003050895,0.000006710851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893832,0.0006411168,0.006535226,0.0001363057,0.00003985535,0.00002556258,0.0007147456,0.0002689083,0.002255109],"genre_scores_gemma":[0.9927158,0.0003277147,0.002619675,0.00004581111,0.000005835704,0.00002016701,0.0006312616,0.0001244817,0.003509292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002011807,"threshold_uncertainty_score":0.006730139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008429320781162243,"score_gpt":0.2246799891894863,"score_spread":0.2162506684083241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}