{"id":"W1806931918","doi":"10.1021/acs.biomac.5b01039","title":"Theranostic, pH-Responsive, Doxorubicin-Loaded Nanoparticles Inducing Active Targeting and Apoptosis for Advanced Gastric Cancer","year":2015,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Ministry of Science and Technology of the People's Republic of China","keywords":"Doxorubicin; Nanocarriers; Chemistry; MTT assay; Apoptosis; Confocal microscopy; Internalization; Cytotoxicity; Cancer cell; Biophysics; Nanoparticle; Amphiphile; Cancer; Biochemistry; Cell; Drug delivery; Nanotechnology; Polymer; Chemotherapy; Materials science; In vitro; Cell biology; Organic chemistry; Biology; Copolymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001809606,0.000232558,0.0003669977,0.0001938291,0.0001231587,0.00004686842,0.0000889135,0.00006787037,0.00002247049],"category_scores_gemma":[0.000416113,0.0001961901,0.00008849413,0.0003523871,0.00009075023,0.0001287579,0.00008120572,0.00007961434,0.000005545784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001293098,"about_ca_system_score_gemma":0.0001213634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001464635,"about_ca_topic_score_gemma":0.00001397704,"domain_scores_codex":[0.9986178,0.000043446,0.0002719258,0.0003941783,0.0002449262,0.0004277631],"domain_scores_gemma":[0.9991195,0.0001463369,0.000139792,0.0001726669,0.0001911067,0.0002306018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001351587,0.00006046717,0.002771012,0.00008285967,0.0001620286,0.00001294609,0.0007012595,0.000009761029,0.9401193,0.00006324227,0.001700658,0.05296491],"study_design_scores_gemma":[0.005478353,0.0004909098,0.01051406,0.0001602113,0.000300294,0.00001335449,0.002069092,0.0001081055,0.977084,0.0001446415,0.003382836,0.0002541399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930237,0.002750379,0.0006590986,0.002096478,0.000271457,0.0008374472,0.00003194299,0.00009508913,0.0002344011],"genre_scores_gemma":[0.9942384,0.0001561191,0.004347323,0.0005846076,0.0001547847,0.000163679,0.00002042734,0.00003895438,0.0002957425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05271077,"threshold_uncertainty_score":0.8000398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03031599484922673,"score_gpt":0.3021327734963767,"score_spread":0.2718167786471499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}