{"id":"W1806931918","doi":"10.1021/acs.biomac.5b01039","title":"Theranostic, pH-Responsive, Doxorubicin-Loaded Nanoparticles Inducing Active Targeting and Apoptosis for Advanced Gastric Cancer","year":2015,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Ministry of Science and Technology of the People's Republic of China","keywords":"Doxorubicin; Nanocarriers; Chemistry; MTT assay; Apoptosis; Confocal microscopy; Internalization; Cytotoxicity; Cancer cell; Biophysics; Nanoparticle; Amphiphile; Cancer; Biochemistry; Cell; Drug delivery; Nanotechnology; Polymer; Chemotherapy; Materials science; In vitro; Cell biology; Organic chemistry; Biology; Copolymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001092012,0.0002134414,0.0001772785,0.0001662939,0.000086047,0.0001390269,0.0001169935,0.0002654671,0.0003016309],"category_scores_gemma":[0.00009378068,0.00009206418,0.0001514956,0.00006882585,0.0001176999,0.0001828083,0.0001428422,0.0002211512,0.0001043855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000304011,"about_ca_system_score_gemma":0.0001646448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004780024,"about_ca_topic_score_gemma":0.0008159272,"domain_scores_codex":[0.9999465,0.000008670083,0.000004393382,0.00001346609,0.00001409597,0.00001287058],"domain_scores_gemma":[0.9999789,0.000003372161,0.000005659352,0.000001815508,0.000005180882,0.000005151031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009695957,0.0000442781,0.0002603873,0.00007819967,0.000006750506,0.00009560084,0.00002745182,0.0002870692,0.9898819,0.0001831809,0.00006844944,0.008969703],"study_design_scores_gemma":[0.00006632559,0.0004830911,0.001667237,0.00001049075,0.00003884383,0.0005480572,0.00001767037,0.00345079,0.9889254,0.00007959214,0.004702242,0.0000103855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777419,0.008964706,0.01089812,0.0003327724,0.00004841303,0.00008571375,0.00006156843,0.00009068869,0.001776151],"genre_scores_gemma":[0.9922622,0.001844539,0.004500631,0.0000871915,0.00001378725,0.00002759078,0.00005506729,0.000006553059,0.00120224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004780024,"threshold_uncertainty_score":0.002205789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03031599484922673,"score_gpt":0.3021327734963767,"score_spread":0.2718167786471499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}