{"id":"W1807669271","doi":"10.1002/9780470921920.edm087","title":"Idiosyncratic Drug Reactions","year":2012,"lang":"en","type":"other","venue":"Encyclopedia of Drug Metabolism and Interactions","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Mechanism (biology); Drug; Circumstantial evidence; Drug reaction; Immune system; Population; Biology; Computational biology; Immunology; Pharmacology; Medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001678046,0.0004776153,0.0009579112,0.0009969273,0.0001222649,0.00002039445,0.0001263719,0.0001971897,0.002422832],"category_scores_gemma":[0.0002068579,0.000435611,0.0003213647,0.0003860349,0.0001695286,0.0003510465,0.00008477841,0.0008922301,0.0005487901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005838107,"about_ca_system_score_gemma":0.000197314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001228929,"about_ca_topic_score_gemma":0.0002883343,"domain_scores_codex":[0.9980451,0.0001023816,0.0006494076,0.0004533492,0.0003466108,0.000403113],"domain_scores_gemma":[0.9979811,0.0001956842,0.0005643864,0.0007370319,0.0001119448,0.0004099065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001800538,0.001223795,0.0003797863,0.0008264976,0.00132337,0.00001827416,0.001721303,0.000001069588,0.0017256,0.004926724,0.9406865,0.0471491],"study_design_scores_gemma":[0.0005666522,0.000004339349,0.003187828,0.0005728941,0.001626377,0.0001855876,0.0008674352,0.000005673032,0.0001936671,0.00006872828,0.9923806,0.0003401738],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.0007644693,0.005421157,0.0000466688,0.0007887455,0.004975788,0.000649264,0.000194044,0.000279767,0.9868801],"genre_scores_gemma":[0.0116899,0.01570179,0.002150657,0.0001006347,0.002702272,0.0001059793,0.0001601763,0.0004437001,0.9669449],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.05169417,"threshold_uncertainty_score":0.9998096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033229284861725,"score_gpt":0.2710312877869642,"score_spread":0.2606989949383469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}