{"id":"W1808615540","doi":"10.1155/2014/549624","title":"Hepatitis C Drugs: The End of the Pegylated Interferon Era and the Emergence of All-Oral, Interferon-Free Antiviral Regimens: A Concise Review","year":2014,"lang":"en","type":"review","venue":"Canadian Journal of Gastroenterology and Hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Merck Canada; AbbVie; Gilead Sciences; Pfizer","keywords":"Simeprevir; Telaprevir; Sofosbuvir; Boceprevir; Medicine; Daclatasvir; Pegylated interferon; Ribavirin; Virology; Ledipasvir; NS5A; NS3; Hepatitis C virus; Protease inhibitor (pharmacology); Ritonavir; Hepatitis C; Pharmacology; Viral load; Hepacivirus; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.002423186,0.0004151502,0.003560667,0.0002609421,0.0001418188,0.00001416845,0.001097655,0.00033531,0.0003016835],"category_scores_gemma":[0.00108494,0.0002031611,0.0005948004,0.0001921992,0.004444255,0.0000764773,0.0002772883,0.001605876,0.000002656218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000105062,"about_ca_system_score_gemma":0.001323281,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.009078014,"about_ca_topic_score_gemma":0.1104727,"domain_scores_codex":[0.9938152,0.003164548,0.001820963,0.0003137722,0.0002737587,0.0006117753],"domain_scores_gemma":[0.9960813,0.0005629053,0.001671724,0.0008948906,0.0004294029,0.0003597723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004438342,0.0001652178,0.1614016,0.05936392,0.008792476,0.0009111005,0.003405376,2.712521e-7,0.000008671115,0.002671513,0.1406999,0.6181417],"study_design_scores_gemma":[0.005210525,0.00696257,0.001439895,0.05224511,0.006285818,0.009576397,0.0001622521,0.00006222293,0.000005336077,0.0002815554,0.9174838,0.0002845066],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01471727,0.9730293,0.00002128719,0.01027651,0.0004829427,0.0010871,0.0001168707,0.000002725057,0.0002660585],"genre_scores_gemma":[0.1363402,0.8614055,0.00003090579,0.002043541,0.00006791216,0.00002560762,0.00001024712,0.00003164223,0.00004445864],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7767839,"threshold_uncertainty_score":0.9982651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03069690247573318,"score_gpt":0.3209827300174994,"score_spread":0.2902858275417662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}