{"id":"W1808615540","doi":"10.1155/2014/549624","title":"Hepatitis C Drugs: The End of the Pegylated Interferon Era and the Emergence of All-Oral, Interferon-Free Antiviral Regimens: A Concise Review","year":2014,"lang":"en","type":"review","venue":"Canadian Journal of Gastroenterology and Hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Merck Canada; AbbVie; Gilead Sciences; Pfizer","keywords":"Simeprevir; Telaprevir; Sofosbuvir; Boceprevir; Medicine; Daclatasvir; Pegylated interferon; Ribavirin; Virology; Ledipasvir; NS5A; NS3; Hepatitis C virus; Protease inhibitor (pharmacology); Ritonavir; Hepatitis C; Pharmacology; Viral load; Hepacivirus; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000972491,0.000745056,0.001549344,0.002037067,0.0002322679,0.00149592,0.0008496171,0.001270749,0.003291465],"category_scores_gemma":[0.001671157,0.0002619255,0.0007061869,0.002191957,0.0003970891,0.002193083,0.0006913202,0.00162832,0.0009479455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005156216,"about_ca_system_score_gemma":0.00165122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008587852,"about_ca_topic_score_gemma":0.001454623,"domain_scores_codex":[0.9996595,0.00007091709,0.00007737672,0.00004390139,0.0001191442,0.00002915844],"domain_scores_gemma":[0.9988318,0.0006267573,0.0002041129,0.00002489472,0.0002410857,0.00007131224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000144133,0.00006817246,0.0002183571,0.03609477,0.0001593483,0.0001975897,0.0001151735,0.000289208,0.0005846493,0.003392056,0.06527673,0.8934599],"study_design_scores_gemma":[0.0000370845,0.0001420569,0.0006532033,0.01158039,0.0002811025,0.001013758,0.00008806606,0.0001255143,0.0001690105,0.001251855,0.9846326,0.00002530941],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000650752,0.9989115,0.00003926909,0.0004097231,0.0003219136,0.00000277681,0.00001408362,0.000003894627,0.0002318314],"genre_scores_gemma":[0.0003705697,0.9986113,0.00007519439,0.0003274769,0.0004359506,0.000003907476,0.00002559973,0.000001025011,0.0001488216],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003291465,"threshold_uncertainty_score":0.011011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03069690247573318,"score_gpt":0.3209827300174994,"score_spread":0.2902858275417662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}