{"id":"W1809676184","doi":"10.1139/cjc-2015-0215","title":"Recognition of an important G-quadruplex in the HIV-1 promoter with natural small molecules","year":2015,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundamental Research Funds for the Central Universities; National Natural Science Foundation of China","keywords":"G-quadruplex; Chemistry; Circular dichroism; Guanosine; Antiparallel (mathematics); Small molecule; Footprinting; Oligonucleotide; Electrospray ionization; Stereochemistry; Molecule; Mass spectrometry; DNA; Biochemistry; Chromatography; Base sequence","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357711,0.0002113293,0.0002256708,0.00008828549,0.0001111415,0.0001465658,0.0002190724,0.0002817849,0.0004734134],"category_scores_gemma":[0.0003051534,0.000124031,0.0001401471,0.00007096213,0.0002409972,0.0001299086,0.0001476407,0.0003575069,0.000203388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002418117,"about_ca_system_score_gemma":0.000187229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003015217,"about_ca_topic_score_gemma":0.0009068503,"domain_scores_codex":[0.9998568,0.00004055795,0.000009079109,0.00003544744,0.00004212113,0.0000159882],"domain_scores_gemma":[0.999831,0.00005333611,0.0000568667,0.00001134494,0.00002146077,0.00002602217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000187775,0.000005234628,0.00005267713,0.0000225309,0.0000013543,0.00001030561,0.000005699697,0.00003815265,0.9993314,0.00002218023,0.00000528174,0.0004865593],"study_design_scores_gemma":[0.000008063765,0.0003020378,0.0006532061,0.000004624037,0.000005766381,0.00009489297,0.000009280026,0.0005786381,0.9973374,0.00002335462,0.0009791641,0.000003515341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873478,0.001962504,0.009327062,0.0001332142,0.00002225946,0.00005935671,0.0001007938,0.0000701301,0.0009767613],"genre_scores_gemma":[0.9838368,0.0007694127,0.01405703,0.0001283155,0.00001200813,0.00004679327,0.000192325,0.00001240525,0.000944999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004734134,"threshold_uncertainty_score":0.001754522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241962019196958,"score_gpt":0.2059128596012933,"score_spread":0.1934932394093237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}