{"id":"W1810350704","doi":"10.1080/15384101.2015.1053671","title":"Mutant lamin A links prophase to a p53 independent senescence program","year":2015,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal","funders":"","keywords":"Biology; Lamin; Nuclear lamina; Cell biology; Prophase; Mitosis; Cytokinesis; Senescence; Mutant; Molecular biology; Genetics; Nuclear protein; Cell division; Gene; Cell; Transcription factor; Meiosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001079304,0.0003421403,0.0001044115,0.0002740541,0.0001766274,0.0003183918,0.0002285008,0.0003522989,0.002182038],"category_scores_gemma":[0.0001206645,0.0001573384,0.0001838156,0.00009779351,0.0002350157,0.0001948152,0.000202578,0.0004525308,0.0005652671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003381831,"about_ca_system_score_gemma":0.0002425252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003985813,"about_ca_topic_score_gemma":0.0004994784,"domain_scores_codex":[0.9999282,0.00001441646,0.000007847908,0.00001467013,0.0000189212,0.0000159016],"domain_scores_gemma":[0.9998447,0.00002281154,0.00004995045,0.00002053919,0.00001409756,0.0000479678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001668699,0.00003473506,0.0001025724,0.00001675018,0.000003825964,0.00009713895,0.000006783019,0.00004566139,0.998669,0.000227223,0.00003710453,0.0005922862],"study_design_scores_gemma":[0.00002789223,0.0004177054,0.002419499,0.000006633268,0.000008234399,0.0006051802,0.00001627686,0.0006732274,0.9925978,0.000255846,0.002966312,0.000005256557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943483,0.0008780646,0.001993943,0.0001394894,0.00004341517,0.00002253267,0.0002329837,0.0001412725,0.002200073],"genre_scores_gemma":[0.9949851,0.0005426711,0.0007240709,0.00004721823,0.00001068819,0.00002045812,0.0003689862,0.00001743257,0.003283413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002182038,"threshold_uncertainty_score":0.007299662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009867748179967424,"score_gpt":0.2482573039935784,"score_spread":0.238389555813611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}