{"id":"W1810679038","doi":"10.1016/j.jmb.2015.08.021","title":"N6-Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding","year":2015,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Center for Chronic Disease Prevention and Health Promotion; National Human Genome Research Institute; National Institute of General Medical Sciences; U.S. Public Health Service; National Institutes of Health; Foundation for the National Institutes of Health","keywords":"N6-Methyladenosine; RNA; RNA-binding protein; Chemistry; Biology; Plasma protein binding; Computational biology; Biochemistry; Cell biology; Methyltransferase; DNA; Gene; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002377833,0.0002388241,0.0002059006,0.0001511454,0.0003471427,0.0002615078,0.0002563159,0.0005881554,0.003488818],"category_scores_gemma":[0.0004490772,0.0001792909,0.0003470664,0.00006808188,0.0002669633,0.0002062413,0.0002623786,0.0007235386,0.0007185888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001710045,"about_ca_system_score_gemma":0.0001718068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003626952,"about_ca_topic_score_gemma":0.000644016,"domain_scores_codex":[0.9998728,0.0000335558,0.000009261453,0.00003162845,0.00002437567,0.00002825005],"domain_scores_gemma":[0.9996495,0.0001088509,0.00007698723,0.00004317814,0.00003008406,0.00009143985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001583126,0.00003483937,0.0008462422,0.00001698962,0.00001144965,0.0005004444,0.0000264318,0.0001447683,0.9963715,0.0003332644,0.00004992627,0.001505848],"study_design_scores_gemma":[0.00002911494,0.0006911317,0.01094993,0.000009645249,0.00004381421,0.002110273,0.00007725223,0.003019587,0.9805503,0.0005451703,0.00194777,0.00002591142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965467,0.0001630709,0.002101438,0.00009012093,0.00004366654,0.00001179351,0.00004038414,0.00005386958,0.0009489256],"genre_scores_gemma":[0.9989147,0.00004616892,0.0005537738,0.00003581693,0.000009514339,0.000004284014,0.00003526299,0.00000869414,0.0003917501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003488818,"threshold_uncertainty_score":0.01167125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02918194626971619,"score_gpt":0.3260171285888837,"score_spread":0.2968351823191675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}