{"id":"W1811805154","doi":"","title":"Flunitrazepam metabolism by cytochrome P450S 2C19 and 3A4.","year":2001,"lang":"en","type":"article","venue":"PubMed","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CYP3A4; Flunitrazepam; Chemistry; CYP1A2; Mephenytoin; Microsome; Cytochrome P450; Ketoconazole; Pharmacology; Metabolite; Metabolism; Pharmacokinetics; Biochemistry; CYP2C19; Enzyme; Biology; Receptor; Benzodiazepine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009101686,0.00034488,0.0004187192,0.0001618471,0.0002905461,0.00005726791,0.0003542855,0.0003269194,0.0008221574],"category_scores_gemma":[0.00008039031,0.0003325181,0.0001108402,0.0003515772,0.000260944,0.0001714471,0.0001592668,0.0006967385,0.0001061045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003110435,"about_ca_system_score_gemma":0.00003059827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003577963,"about_ca_topic_score_gemma":0.000005106796,"domain_scores_codex":[0.9975372,0.0003537178,0.0003918367,0.000491912,0.0002301774,0.0009951507],"domain_scores_gemma":[0.9985597,0.0001940477,0.0001222217,0.0002552534,0.00008139291,0.0007873774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004608187,0.000647568,0.009310569,0.00004508182,0.0006266934,0.0001434543,0.0004575604,0.00004574622,0.09153266,0.001943753,0.0535921,0.841194],"study_design_scores_gemma":[0.002204342,0.00001039864,0.1105381,0.000001260013,0.0003139973,0.00008760084,0.00002520565,0.0002438789,0.02184818,0.0008280687,0.8635207,0.0003783148],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9495005,0.02008652,0.00005912569,0.00177004,0.00147583,0.001012099,0.000177775,0.0001801122,0.02573802],"genre_scores_gemma":[0.9788272,0.008329825,0.00008745158,0.005914652,0.000655096,0.001136003,0.00003796586,0.00005147946,0.004960286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8408157,"threshold_uncertainty_score":0.9999127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09584527878852,"score_gpt":0.3754610337923706,"score_spread":0.2796157550038506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}