{"id":"W1811805154","doi":"","title":"Flunitrazepam metabolism by cytochrome P450S 2C19 and 3A4.","year":2001,"lang":"en","type":"article","venue":"PubMed","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CYP3A4; Flunitrazepam; Chemistry; CYP1A2; Mephenytoin; Microsome; Cytochrome P450; Ketoconazole; Pharmacology; Metabolite; Metabolism; Pharmacokinetics; Biochemistry; CYP2C19; Enzyme; Biology; Receptor; Benzodiazepine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027781,0.0003780062,0.0002563948,0.0003636631,0.0001967763,0.0003037717,0.0001455872,0.0003008466,0.002002221],"category_scores_gemma":[0.0003562438,0.0001787907,0.0005389657,0.0003019071,0.0001960996,0.000172671,0.000108917,0.000379558,0.0005729849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004673686,"about_ca_system_score_gemma":0.0002965559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005886117,"about_ca_topic_score_gemma":0.004802924,"domain_scores_codex":[0.9997941,0.00006598825,0.00001508533,0.00003762164,0.00005324764,0.00003387946],"domain_scores_gemma":[0.9998647,0.00002823477,0.00005048347,0.0000125382,0.00003170263,0.00001232754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001030791,0.0000955588,0.01691431,0.0003194182,0.0002470962,0.0007105342,0.00007499602,0.0005921823,0.911647,0.0006140671,0.0008780455,0.06687604],"study_design_scores_gemma":[0.000222391,0.001593249,0.1066511,0.00002507019,0.0003254245,0.007071593,0.00005266746,0.004383195,0.8408905,0.0006029035,0.03815177,0.00003014049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8809845,0.06468657,0.03819953,0.001289409,0.0001828653,0.0004377056,0.002136309,0.0004170238,0.01166613],"genre_scores_gemma":[0.9734271,0.009399259,0.009819032,0.0001979838,0.00009113766,0.0000935632,0.001740764,0.00002460232,0.005206609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005886117,"threshold_uncertainty_score":0.01170367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09584527878852,"score_gpt":0.3754610337923706,"score_spread":0.2796157550038506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}