{"id":"W1814829563","doi":"10.1002/ijc.28369","title":"Lovastatin‐induced apoptosis is mediated by activating transcription factor 3 and enhanced in combination with salubrinal","year":2013,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Lovastatin; Apoptosis; HeLa; Cytotoxicity; Cancer research; Biology; Integrated stress response; Activating transcription factor; ATF3; Cell culture; Transcription factor; Cell biology; Chemistry; Gene expression; Biochemistry; Unfolded protein response; Cholesterol; In vitro; Messenger RNA; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001150971,0.0003172915,0.0005578416,0.0004154657,0.000178754,0.0002795879,0.0002175077,0.0002229089,0.0008000874],"category_scores_gemma":[0.0001124357,0.0001001816,0.0005154757,0.0002486683,0.0001728359,0.0001586119,0.0001898309,0.0004365757,0.0002990413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000373535,"about_ca_system_score_gemma":0.0002816181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008236588,"about_ca_topic_score_gemma":0.002316194,"domain_scores_codex":[0.9998184,0.00003375405,0.00002213168,0.00002438049,0.00005276053,0.00004852992],"domain_scores_gemma":[0.9999261,0.000011326,0.00002111096,0.00001200066,0.000008493543,0.00002098787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004517507,0.00008504941,0.0002070902,0.00006662172,0.000015534,0.00006992686,0.00001784799,0.00005954179,0.9960331,0.00004926763,0.0000880271,0.002856097],"study_design_scores_gemma":[0.00003487739,0.000556826,0.002526114,0.000005412722,0.00002905125,0.0002071272,0.0000161082,0.0005685437,0.9922258,0.00003332731,0.003791969,0.000004894821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883347,0.004725373,0.003498866,0.0002325535,0.00009407084,0.0001057535,0.0005766449,0.0001882859,0.002243906],"genre_scores_gemma":[0.9950883,0.001415505,0.001489571,0.00007133235,0.00001958171,0.0000459559,0.0005448835,0.00001865932,0.001306297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008236588,"threshold_uncertainty_score":0.002710223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009047869565518516,"score_gpt":0.2698118600395644,"score_spread":0.2607639904740459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}