{"id":"W1815740324","doi":"10.1016/j.celrep.2015.04.056","title":"Single Transcription Factor Conversion of Human Blood Fate to NPCs with CNS and PNS Developmental Capacity","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Transcription factor; Cell biology; Biology; Neuroscience; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002578938,0.0001918207,0.0001545077,0.0002182187,0.0001485991,0.0003717331,0.0001468607,0.0001533713,0.002172042],"category_scores_gemma":[0.0002627426,0.0001016907,0.000185824,0.0001423409,0.000158594,0.0001212887,0.0002400239,0.0003274722,0.0005394724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002180332,"about_ca_system_score_gemma":0.0003008836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008289894,"about_ca_topic_score_gemma":0.001539339,"domain_scores_codex":[0.9998665,0.0000219636,0.00002000541,0.00003200315,0.00004351154,0.00001598631],"domain_scores_gemma":[0.9998741,0.00003142938,0.0000220264,0.00003141386,0.00002436272,0.00001662911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001009552,0.00003286603,0.0007982244,0.00006994297,0.00000821549,0.0001592673,0.00005639237,0.0001627112,0.9868143,0.0006040803,0.0003494345,0.0108437],"study_design_scores_gemma":[0.000008996242,0.00009658589,0.002024915,0.000008923883,0.00001688054,0.0004166198,0.00001840923,0.0005830844,0.9873362,0.00008470217,0.009401803,0.000002944472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9263924,0.001888762,0.04886867,0.0002079911,0.00009044095,0.0004158697,0.002996564,0.0005110677,0.01862825],"genre_scores_gemma":[0.9673931,0.001066343,0.01932144,0.00008740801,0.00001282775,0.0002504302,0.00265682,0.00006839449,0.009143357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002172042,"threshold_uncertainty_score":0.007266223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0350300296193387,"score_gpt":0.24195503620447,"score_spread":0.2069250065851313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}