{"id":"W181574387","doi":"10.1007/82_2010_92","title":"Small Molecule Inhibitors of the Human Papillomavirus E1-E2 Interaction","year":2010,"lang":"en","type":"article","venue":"Current topics in microbiology and immunology","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Transactivation; DNA; DNA replication; Small molecule; Binding site; Biology; Computational biology; Bovine papillomavirus; Chemistry; Virology; Genetics; Transcription factor; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001815707,0.0004702171,0.0004119333,0.0002254249,0.000248286,0.0003562282,0.0002640107,0.0003253772,0.005219841],"category_scores_gemma":[0.0001571188,0.0001516909,0.0002916435,0.0001529192,0.0001529568,0.0001812715,0.000207867,0.0007227596,0.0007926206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002610868,"about_ca_system_score_gemma":0.0002137234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005246664,"about_ca_topic_score_gemma":0.00127886,"domain_scores_codex":[0.9999262,0.00001503909,0.000004189256,0.00001024546,0.00001528593,0.00002905517],"domain_scores_gemma":[0.9999549,0.00002018088,0.000005821062,0.000003320238,0.000004368168,0.00001133862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003294698,0.000941884,0.0006440452,0.0006556453,0.0001852867,0.0005260571,0.00008955145,0.001370047,0.918039,0.002869558,0.004193885,0.06719039],"study_design_scores_gemma":[0.001757461,0.006679522,0.006060373,0.00007945158,0.0001826208,0.001507309,0.00008649898,0.003359778,0.9101633,0.0007470212,0.06933387,0.00004281797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9073031,0.05651522,0.008461568,0.001070113,0.0008118183,0.0004611863,0.001428616,0.0005030394,0.02344528],"genre_scores_gemma":[0.9515962,0.02561263,0.002998281,0.0004085913,0.0001526694,0.0002217489,0.001375207,0.0000351301,0.01759955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005219841,"threshold_uncertainty_score":0.01746213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0367442608625131,"score_gpt":0.3391360748953874,"score_spread":0.3023918140328743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}