{"id":"W1816176398","doi":"10.1126/science.aaa0355","title":"The human transcriptome across tissues and individuals","year":2015,"lang":"en","type":"article","venue":"Science","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1427,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Human Genome Research Institute; H2020 European Research Council; National Institute on Drug Abuse; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Cancer Institute; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Heart, Lung, and Blood Institute; Louis-Jeantet Foundation","keywords":"Biology; Genetic variation; Transcriptome; Gene; Gene expression; Expression quantitative trait loci; Genetics; Genotype; Regulation of gene expression; Evolutionary biology; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000275885,0.0001113607,0.0002613502,0.0006358202,0.0002429865,0.000535958,0.00009735129,0.0002168937,0.001517758],"category_scores_gemma":[0.0007496604,0.0001271914,0.0001833662,0.0009047997,0.0002306184,0.0001545579,0.0003297517,0.0001955777,0.0005412633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001578855,"about_ca_system_score_gemma":0.000159448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001482864,"about_ca_topic_score_gemma":0.001965949,"domain_scores_codex":[0.9996221,0.00007076345,0.0000204507,0.0001923717,0.00006328947,0.00003098456],"domain_scores_gemma":[0.999721,0.00009611865,0.00004815147,0.00006371943,0.00005315181,0.00001780512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009990907,0.00005615018,0.2897239,0.0003120294,0.000574963,0.0009911455,0.002145179,0.00128573,0.5287681,0.001832161,0.005051781,0.1682598],"study_design_scores_gemma":[0.00001191492,0.00009705844,0.9628588,0.00004133367,0.0001299088,0.001935836,0.000525383,0.0007735764,0.01348739,0.002374691,0.01774239,0.0000217299],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623461,0.003452358,0.008440292,0.0003251251,0.000047582,0.00002781066,0.01826492,0.0001644033,0.006931422],"genre_scores_gemma":[0.9761264,0.002042521,0.005139428,0.0003670343,0.00003597892,0.00006585944,0.01406919,0.0001054799,0.002048004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001517758,"threshold_uncertainty_score":0.005077362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01713712829391614,"score_gpt":0.3040345171503239,"score_spread":0.2868973888564078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}