{"id":"W1816850522","doi":"10.1093/annonc/mdu330.27","title":"The Herby Study: a Phase 2 Open-Label, Randomized, Multicenter Study of Bevacizumab-Based Therapy in Pediatric Patients with Newly Diagnosed High-Grade Glioma","year":2014,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Bevacizumab; Glioma; Open label; Randomized controlled trial; Oncology; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001334973,0.001382664,0.002515682,0.0004096057,0.0005041872,0.000751667,0.0007144827,0.001318383,0.002752175],"category_scores_gemma":[0.001369944,0.0004907215,0.001194343,0.0004855139,0.0009918838,0.001184889,0.0004368492,0.002727925,0.0003896037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001023731,"about_ca_system_score_gemma":0.002295448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001987611,"about_ca_topic_score_gemma":0.007003358,"domain_scores_codex":[0.9995663,0.000230453,0.00001687929,0.0000654341,0.00004687634,0.00007411119],"domain_scores_gemma":[0.9993686,0.0001518826,0.0001806719,0.00003783391,0.00003630764,0.0002245827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.845156,0.03334873,0.0114538,0.001622476,0.003500315,0.0004174224,0.0004228129,0.001754158,0.01608264,0.0008286056,0.007191491,0.0782216],"study_design_scores_gemma":[0.9172221,0.06974156,0.008524015,0.00004352698,0.0007787023,0.0001485423,0.00007551527,0.0004052254,0.0006987096,0.0001899093,0.002145863,0.0000263242],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901657,0.00283157,0.0005711332,0.000956231,0.0002015531,0.002939506,0.001231981,0.00006895798,0.001033377],"genre_scores_gemma":[0.97219,0.005798471,0.006162897,0.002641465,0.0005786914,0.007262887,0.002615834,0.00007954155,0.002670372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002752175,"threshold_uncertainty_score":0.009206951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05287409813008815,"score_gpt":0.3818281851698588,"score_spread":0.3289540870397707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}