{"id":"W1817128706","doi":"10.3233/jad-2012-100732","title":"Early Increases in Soluble Amyloid-β Levels Coincide with Cholinergic Degeneration in 3xTg-AD Mice","year":2012,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Fundação para a Ciência e a Tecnologia; Canadian Institutes of Health Research; Scottish Rite Charitable Foundation of Canada","keywords":"Cholinergic; Degeneration (medical); Cholinergic neuron; Genetically modified mouse; Hippocampal formation; Cholinergic Fibers; Amyloid (mycology); Disease; Neuroscience; Medicine; Alzheimer's disease; Internal medicine; Pathology; Endocrinology; Biology; Transgene; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000297223,0.0009955083,0.0008011655,0.002237192,0.0004855958,0.0007610165,0.0004350019,0.00140286,0.002359448],"category_scores_gemma":[0.0002593627,0.0005830281,0.0007875942,0.0007193547,0.000710256,0.0007478901,0.0004919692,0.002186,0.001207148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005747292,"about_ca_system_score_gemma":0.0002620331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001391037,"about_ca_topic_score_gemma":0.002305252,"domain_scores_codex":[0.9996915,0.0000246568,0.00005055793,0.00009174164,0.00007249475,0.00006914556],"domain_scores_gemma":[0.9991996,0.00005559484,0.0003745738,0.00005078955,0.00006189172,0.0002574622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006949458,0.0001548319,0.001058228,0.00003786904,0.00001797295,0.0003702885,0.0001433653,0.0000379421,0.996088,0.00008279638,0.00008417061,0.001229552],"study_design_scores_gemma":[0.0001672851,0.001836306,0.1055525,0.00006813188,0.0001229141,0.003236832,0.0004235283,0.0007796314,0.8841913,0.0005642789,0.002993042,0.00006415504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929173,0.001379097,0.001472296,0.0001415441,0.000040951,0.00006396134,0.002297498,0.0003072151,0.001380133],"genre_scores_gemma":[0.9789903,0.002496591,0.005017848,0.0002435162,0.00004244421,0.0002919663,0.003109616,0.0002552028,0.00955265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002359448,"threshold_uncertainty_score":0.007893145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04445620382655827,"score_gpt":0.319992835658466,"score_spread":0.2755366318319077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}