{"id":"W1818129319","doi":"10.1586/14737159.2015.1063421","title":"Predictive and prognostic cancer biomarkers revisited","year":2015,"lang":"en","type":"review","venue":"Expert Review of Molecular Diagnostics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cancer; Medicine; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005080584,0.000775796,0.002269592,0.0001362777,0.00004958968,0.00003393934,0.0005169331,0.0004965949,0.00002249325],"category_scores_gemma":[0.003316354,0.0006821944,0.0006059737,0.0003760714,0.0002570758,0.000004797742,0.0005397647,0.0002513699,0.000009084019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009701275,"about_ca_system_score_gemma":0.001052519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000255372,"about_ca_topic_score_gemma":0.000003097924,"domain_scores_codex":[0.9967999,0.000309205,0.001128291,0.0009132398,0.0004186665,0.0004307379],"domain_scores_gemma":[0.9970134,0.00026948,0.0008235378,0.001001267,0.0005406861,0.000351632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001539932,0.0001268894,0.00002271534,0.0896987,0.001043941,0.00005908102,0.00001633703,0.0000012646,0.00007014952,0.00008567218,0.1266945,0.7821653],"study_design_scores_gemma":[0.0002359517,0.0003123264,0.000002253713,0.1113161,0.001663289,0.00004441381,0.000005392529,0.000002467424,0.0001280028,0.00001982922,0.8856673,0.000602644],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000005470498,0.9951233,0.0004876907,0.00007636588,0.0003912121,0.002394297,0.0009969751,0.00001712629,0.000507561],"genre_scores_gemma":[0.000002781025,0.9943979,0.001102111,0.0014213,0.0004388907,0.0008258002,0.001627764,0.0001575455,0.00002587869],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7815627,"threshold_uncertainty_score":0.9995629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01873979675133194,"score_gpt":0.3432180555444364,"score_spread":0.3244782587931044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}