{"id":"W1818178467","doi":"10.1039/c5an00996k","title":"Naked-eye nanobiosensor for therapeutic drug monitoring of methotrexate","year":2015,"lang":"en","type":"article","venue":"The Analyst","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Institut Mérieux; Canada Foundation for Innovation","keywords":"Methotrexate; Therapeutic drug monitoring; Naked eye; Drug; Pharmacology; Medicine; Nanotechnology; Chemistry; Materials science; Internal medicine; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005914329,0.0006857582,0.0006764283,0.0004453458,0.0003016505,0.000544941,0.0007712322,0.0009158131,0.001918175],"category_scores_gemma":[0.001012308,0.0004304691,0.0003321923,0.000167837,0.0004560113,0.0005277196,0.0007287855,0.0007871403,0.001138789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005378556,"about_ca_system_score_gemma":0.0004117808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004871854,"about_ca_topic_score_gemma":0.001013102,"domain_scores_codex":[0.9989519,0.0002296385,0.0000578556,0.0002771679,0.000433231,0.00005016639],"domain_scores_gemma":[0.9995494,0.0001888681,0.00008021232,0.00005722127,0.00008048012,0.00004386466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003477278,0.00000802767,0.00004867503,0.00005444555,0.000004002977,0.00003447389,0.00002110406,0.00005393125,0.9968392,0.0001259974,0.0001245602,0.002650855],"study_design_scores_gemma":[0.000008527983,0.00009276105,0.000386036,0.000007317998,0.00001510607,0.0002152358,0.0000123575,0.002327658,0.9943177,0.00007638907,0.00252867,0.0000123599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.4756917,0.01333883,0.4897347,0.001356536,0.0008953428,0.0003239932,0.0009176165,0.004739976,0.01300125],"genre_scores_gemma":[0.6784434,0.003735255,0.2992518,0.00066896,0.000132372,0.0003801208,0.0005751224,0.0002026769,0.01661019],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001918175,"threshold_uncertainty_score":0.006416917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03509918214998959,"score_gpt":0.3325087026962419,"score_spread":0.2974095205462523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}