{"id":"W1819808716","doi":"10.1139/v11-108","title":"Development of a copper(II)-catalyzed three-component tandem synthesis of isoindolinone derivatives","year":2011,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Alkyne; Propargyl; Tandem; Combinatorial chemistry; DNA gyrase; Catalysis; Amine gas treating; Aldehyde; Cascade reaction; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003277312,0.0002454911,0.0006818682,0.0001130498,0.0001367233,0.0000068575,0.0005900789,0.0001852194,0.004729304],"category_scores_gemma":[0.0003140841,0.0002358585,0.0002190599,0.0001282337,0.0003964658,0.00009793703,0.00004188061,0.0002646884,0.000002319508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001265419,"about_ca_system_score_gemma":0.001837135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002522494,"about_ca_topic_score_gemma":0.0003426442,"domain_scores_codex":[0.9981781,0.00001896332,0.001043987,0.0001805398,0.0002366525,0.0003417105],"domain_scores_gemma":[0.9976984,0.0001689917,0.001078232,0.0002394002,0.000315747,0.0004992579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008760865,0.0001403811,0.01037836,0.0002947487,0.0005225274,0.00004517097,0.004452375,0.000002262794,0.9795017,0.000008839397,0.0002807791,0.004285276],"study_design_scores_gemma":[0.00053032,0.00001310244,0.007290437,0.0004518473,0.00007765653,0.00007415719,0.001242492,0.000006883709,0.988633,0.00007326176,0.00139096,0.0002159251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867194,0.0008811996,0.00004284166,0.00007477228,0.0000653289,0.0000366455,0.00004900613,0.000005863519,0.0121249],"genre_scores_gemma":[0.9950062,0.00002653312,0.004752337,0.00001608702,0.00009810878,0.000006985234,0.000005515887,0.00002564148,0.00006256569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01206233,"threshold_uncertainty_score":0.9961805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03773786385963178,"score_gpt":0.2374494756423292,"score_spread":0.1997116117826974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}