{"id":"W1820767944","doi":"10.1523/jneurosci.20-10-03705.2000","title":"Wild-Type Huntingtin Protects from Apoptosis Upstream of Caspase-3","year":2000,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":395,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; Hereditary Disease Foundation; National Institutes of Health; Consiglio Nazionale delle Ricerche; Strong; U.S. Public Health Service","keywords":"Huntingtin; Biology; Cell biology; Mutant; Huntingtin Protein; Wild type; Apoptosis; Programmed cell death; Caspase; Huntington's disease; Mutation; Molecular biology; Genetics; Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001148093,0.0002028763,0.0002284309,0.00014331,0.0001175834,0.000277418,0.0002165492,0.0001933018,0.0009039423],"category_scores_gemma":[0.0001603133,0.00009595187,0.0001513528,0.00009250471,0.000173664,0.000152825,0.0001210364,0.0004567456,0.0003284424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001661623,"about_ca_system_score_gemma":0.0001794037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003454214,"about_ca_topic_score_gemma":0.0005047147,"domain_scores_codex":[0.9999022,0.00001585485,0.00001605514,0.00001644115,0.0000232245,0.00002616255],"domain_scores_gemma":[0.9998579,0.00003379207,0.00002535816,0.00003276277,0.00001813976,0.00003204233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001733133,0.000062947,0.0001526011,0.00002843473,0.000006349659,0.00007252987,0.00001317413,0.00003949147,0.9983204,0.0001007796,0.00005052264,0.0009795125],"study_design_scores_gemma":[0.00007641033,0.001038347,0.00798758,0.00001228366,0.00002285151,0.0007813985,0.00003716995,0.0008117391,0.9869919,0.0001699242,0.002064432,0.000006044875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978678,0.0007214569,0.0006157906,0.00004180096,0.0000209097,0.000008622217,0.0001611069,0.0000343306,0.0005281184],"genre_scores_gemma":[0.9971636,0.0004389407,0.0006229235,0.00003543992,0.00000718546,0.00001183122,0.0005956464,0.000008852962,0.001115604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009039423,"threshold_uncertainty_score":0.003023982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03637928876880873,"score_gpt":0.2728292860174387,"score_spread":0.2364499972486299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}