{"id":"W1820767944","doi":"10.1523/jneurosci.20-10-03705.2000","title":"Wild-Type Huntingtin Protects from Apoptosis Upstream of Caspase-3","year":2000,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":395,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; Hereditary Disease Foundation; National Institutes of Health; Consiglio Nazionale delle Ricerche; Strong; U.S. Public Health Service","keywords":"Huntingtin; Biology; Cell biology; Mutant; Huntingtin Protein; Wild type; Apoptosis; Programmed cell death; Caspase; Huntington's disease; Mutation; Molecular biology; Genetics; Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000193665,0.0001988342,0.0003201123,0.0001731441,0.0001607774,0.00008130255,0.0009065622,0.00003988854,0.0002193561],"category_scores_gemma":[0.002339415,0.0001650313,0.0001541893,0.001031459,0.0003834682,0.0003608303,0.00007166863,0.0002644676,0.00002546983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001914337,"about_ca_system_score_gemma":0.0002042459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002175763,"about_ca_topic_score_gemma":0.000001229306,"domain_scores_codex":[0.9974077,0.0002969291,0.0006248212,0.0004408734,0.0008918219,0.0003378509],"domain_scores_gemma":[0.9983781,0.0002559807,0.0005844536,0.0003790778,0.0001730735,0.0002293177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008573908,0.0002237058,0.001483751,0.000006227291,0.000001140205,0.00003709707,0.00009940661,0.001197936,0.9930534,0.00001561726,0.0002173495,0.003578647],"study_design_scores_gemma":[0.0003319664,0.0006101162,0.01595807,0.00004507545,0.00001925454,0.00007017652,0.00001683139,0.0002497495,0.9812417,0.0001758107,0.001144807,0.0001364245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982648,0.00004063403,0.00005819007,0.0003123024,0.0005990323,0.0001815547,0.00002631598,0.00001791423,0.0004992957],"genre_scores_gemma":[0.9979007,0.0001393533,0.0004661609,0.001067624,0.0001244713,0.000002458321,1.7048e-7,0.00002051966,0.0002785247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01447432,"threshold_uncertainty_score":0.672978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03637928876880873,"score_gpt":0.2728292860174387,"score_spread":0.2364499972486299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}