{"id":"W1821163671","doi":"10.1016/j.ibmb.2015.05.006","title":"Disruption of insect isoprenoid biosynthesis with pyridinium bisphosphonates","year":2015,"lang":"en","type":"article","venue":"Insect Biochemistry and Molecular Biology","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Forest Service; Natural Resources Canada","funders":"Canadian Forest Service; Natural Sciences and Engineering Research Council of Canada; Herman Frasch Foundation for Chemical Research","keywords":"Manduca sexta; Mevalonate pathway; Biology; Biochemistry; Bombyx mori; Terpenoid; Mevalonic acid; Biosynthesis; Drosophila melanogaster; Insect; Botany; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000283349,0.0004000605,0.0003777117,0.00006183029,0.00006939512,0.00002173677,0.0003125336,0.0005430203,0.00001408395],"category_scores_gemma":[0.0002784826,0.000331403,0.0001204968,0.0001970026,0.0005470837,0.00000704618,0.000190632,0.0001478158,0.000003224285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001991451,"about_ca_system_score_gemma":0.0002003319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007062103,"about_ca_topic_score_gemma":0.00001108764,"domain_scores_codex":[0.9982604,0.00009289632,0.0003451743,0.0007361415,0.0001593868,0.0004059575],"domain_scores_gemma":[0.9987662,0.00003665346,0.0002179521,0.0005313466,0.0001840448,0.00026379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008300542,0.0001256247,0.003613635,0.00008717518,0.0001711813,0.0000196201,0.0000289723,0.000006145055,0.9933774,0.00006874406,0.0002797134,0.00139169],"study_design_scores_gemma":[0.0007907975,0.0007241144,0.000218433,0.00005089824,0.00007101276,0.0002598111,0.0001105838,0.00001414907,0.993105,0.0001403472,0.004060621,0.0004542266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940109,0.003026159,0.0007987691,0.0002012068,0.00007268739,0.0001568253,0.0002041265,0.00003361544,0.001495714],"genre_scores_gemma":[0.9976258,0.0002609611,0.001077991,0.0002017629,0.0001087031,0.00002795524,0.0004912651,0.00003378236,0.0001718075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003780908,"threshold_uncertainty_score":0.9999138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01365985697821482,"score_gpt":0.2340413424330069,"score_spread":0.2203814854547921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}