{"id":"W1821171706","doi":"10.1039/c5cc03623b","title":"Synthesis of 3-chloro-6-((4-(di-tert-butyl[<sup>18</sup>F]fluorosilyl)-benzyl)oxy)-1,2,4,5-tetrazine ([<sup>18</sup>F]SiFA-OTz) for rapid tetrazine-based<sup>18</sup>F-radiolabeling","year":2015,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Tetrazine; Bioorthogonal chemistry; Yield (engineering); Chemistry; Radiochemistry; Medicinal chemistry; Combinatorial chemistry; Organic chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001096678,0.0003803815,0.0003116431,0.0001966516,0.0001559885,0.0001508869,0.0003710514,0.0003794627,0.002265229],"category_scores_gemma":[0.0001161168,0.0002089853,0.0002111569,0.0002155859,0.0001330634,0.00017354,0.0001814831,0.0003898794,0.001298877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000244021,"about_ca_system_score_gemma":0.0003304352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006742789,"about_ca_topic_score_gemma":0.001338341,"domain_scores_codex":[0.9999336,0.000005888508,0.000004663586,0.0000168317,0.00001461954,0.00002434897],"domain_scores_gemma":[0.9999499,0.000007754604,0.00001121858,0.00000636174,0.0000101313,0.00001457167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004069092,0.0000103128,0.000037092,0.00004970743,0.000004701448,0.00007109533,0.00001510751,0.000182041,0.9969968,0.0002283027,0.00006748088,0.00229669],"study_design_scores_gemma":[0.00001586142,0.0001959039,0.0004725537,0.000004409339,0.000009173329,0.0001558198,0.000008720673,0.0006519042,0.9930032,0.0000523168,0.005421375,0.00000884405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9343842,0.002879029,0.05062955,0.0001896453,0.000129212,0.0002702095,0.001447324,0.0006544109,0.009416295],"genre_scores_gemma":[0.9707582,0.001554047,0.01888437,0.00007071425,0.00001463596,0.0001188733,0.001072994,0.00006084768,0.007465478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002265229,"threshold_uncertainty_score":0.007577896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07812139806041583,"score_gpt":0.3103430680745364,"score_spread":0.2322216700141206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}