{"id":"W1821171706","doi":"10.1039/c5cc03623b","title":"Synthesis of 3-chloro-6-((4-(di-tert-butyl[<sup>18</sup>F]fluorosilyl)-benzyl)oxy)-1,2,4,5-tetrazine ([<sup>18</sup>F]SiFA-OTz) for rapid tetrazine-based<sup>18</sup>F-radiolabeling","year":2015,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Tetrazine; Bioorthogonal chemistry; Yield (engineering); Chemistry; Radiochemistry; Medicinal chemistry; Combinatorial chemistry; Organic chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","open_science","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001206256,0.001568053,0.002000086,0.0003294083,0.001144216,0.0002849268,0.00625194,0.00145611,0.001848422],"category_scores_gemma":[0.004429216,0.001718478,0.001268711,0.001541194,0.001669067,0.0005532581,0.001449187,0.002212691,0.0002423363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008785434,"about_ca_system_score_gemma":0.0007977415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001844542,"about_ca_topic_score_gemma":0.00001390141,"domain_scores_codex":[0.9917825,0.0002327312,0.003002948,0.00191407,0.001213784,0.001853908],"domain_scores_gemma":[0.9811938,0.006378335,0.001042129,0.008610669,0.001352167,0.001422843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006978731,0.005743352,0.003240333,0.002304282,0.001113,0.0000111416,0.001891922,0.008612042,0.8978283,0.00155615,0.0626168,0.01438479],"study_design_scores_gemma":[0.003367572,0.00007648201,0.00003350875,0.0008054476,0.000833636,0.00006662364,0.001805577,0.09615743,0.8030446,0.0009833666,0.09105959,0.001766192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9156578,0.007207979,0.002758465,0.008255932,0.0001030959,0.002852077,0.006107827,0.001857102,0.05519978],"genre_scores_gemma":[0.9741693,0.0007131082,0.01437212,0.0004599207,0.0007717332,0.003525863,0.004305174,0.0003810018,0.001301805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09478373,"threshold_uncertainty_score":0.9998402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07812139806041583,"score_gpt":0.3103430680745364,"score_spread":0.2322216700141206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}