{"id":"W1821215690","doi":"","title":"The energy sensor AMP-activated protein kinase (AMPK) signals neuronal death in glaucoma through inhibition of the mammalian target of rapamycin (mTOR).","year":2015,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"AMPK; PI3K/AKT/mTOR pathway; AMP-activated protein kinase; Protein kinase A; Cell biology; Chemistry; Kinase; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002001487,0.0003395445,0.0002296823,0.0006522789,0.0003468987,0.0007387058,0.000200281,0.00039344,0.001412967],"category_scores_gemma":[0.0002252829,0.000175145,0.0002292395,0.0003483647,0.0005383178,0.0005186385,0.0005435147,0.0006696928,0.0004967956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005435963,"about_ca_system_score_gemma":0.0003559035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006168543,"about_ca_topic_score_gemma":0.0009751836,"domain_scores_codex":[0.999822,0.00003294739,0.00001555202,0.00002754549,0.00006503675,0.00003697129],"domain_scores_gemma":[0.9998899,0.00001051968,0.00005234949,0.000007384352,0.00002024139,0.00001961878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001136441,0.000141194,0.004235334,0.0006461784,0.0000757036,0.001020047,0.0001000294,0.0004058635,0.9247527,0.006420744,0.003088407,0.05797739],"study_design_scores_gemma":[0.0001805154,0.001259135,0.08013197,0.0001897191,0.000195137,0.005019794,0.0005880389,0.00230948,0.8508645,0.009166452,0.05003207,0.00006311231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8381383,0.1216978,0.007536696,0.004827351,0.001624212,0.00008826303,0.001299377,0.0003860509,0.02440196],"genre_scores_gemma":[0.9627981,0.03015774,0.001934595,0.00046125,0.0001593329,0.00002681862,0.0003346321,0.00002690344,0.004100607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001412967,"threshold_uncertainty_score":0.004726827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03459697143572229,"score_gpt":0.2984908277038835,"score_spread":0.2638938562681613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}