{"id":"W1823273489","doi":"10.1158/1078-0432.712.11.2","title":"Targeting Cyclooxygenase-2 Reduces Overt Toxicity toward Low-Dose Vinblastine and Extends Survival of Juvenile Mice with Friend Disease","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Vinblastine; Juvenile; Toxicity; Cyclooxygenase; Disease; Medicine; Pharmacology; Cancer research; Internal medicine; Oncology; Biology; Chemotherapy; Enzyme; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385912,0.0004313868,0.000302428,0.0001941202,0.0001043963,0.0001837388,0.0001679555,0.0002189576,0.0007521313],"category_scores_gemma":[0.0001075246,0.00009771569,0.000162338,0.0001012695,0.0001599565,0.0001744919,0.00009575819,0.0004384203,0.0001560987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001770349,"about_ca_system_score_gemma":0.0001455436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005478264,"about_ca_topic_score_gemma":0.001543347,"domain_scores_codex":[0.9999098,0.00001711006,0.000007899619,0.00001723768,0.00002214556,0.00002589484],"domain_scores_gemma":[0.9998553,0.0000128958,0.00006525568,0.00001112119,0.000009971226,0.00004547026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000523052,0.0001147895,0.000382853,0.00002654998,0.00000541704,0.00003582609,0.00001277215,0.00005612163,0.9973527,0.00002428448,0.00003141309,0.001434108],"study_design_scores_gemma":[0.0001293305,0.009652421,0.01489957,0.00001192017,0.00004866974,0.0004559218,0.00005754727,0.0007365955,0.9716092,0.00002756933,0.002364004,0.000007158592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977524,0.0008034918,0.000728977,0.00003334579,0.00001186782,0.00002450901,0.0002084146,0.00004031164,0.000396725],"genre_scores_gemma":[0.9961178,0.0008088557,0.0009419812,0.00002527162,0.00001099617,0.00003830949,0.0004228128,0.00001191641,0.001622136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007521313,"threshold_uncertainty_score":0.002516091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08365343658399149,"score_gpt":0.4381873482233783,"score_spread":0.3545339116393868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}