{"id":"W1823812337","doi":"10.1593/neo.10296","title":"An Anti-Urokinase Plasminogen Activator Receptor Antibody (ATN-658) Blocks Prostate Cancer Invasion, Migration, Growth, and Experimental Skeletal Metastasis In Vitro and In Vivo","year":2010,"lang":"en","type":"article","venue":"Neoplasia","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Urokinase receptor; Metastasis; Cancer research; Biology; Protein kinase B; Prostate cancer; Pathology; Cancer; Medicine; Plasminogen activator; Signal transduction; Endocrinology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357906,0.0002359675,0.0002173206,0.0001099663,0.0000816365,0.00005176221,0.0001080048,0.0002086165,0.00004593396],"category_scores_gemma":[0.00004075333,0.0002092417,0.00003419755,0.0001181411,0.0000884087,0.00004207699,0.00008631439,0.0001959566,0.00000117176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001282001,"about_ca_system_score_gemma":0.00009445919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003635589,"about_ca_topic_score_gemma":0.0006572428,"domain_scores_codex":[0.9987241,0.0000701188,0.0002423762,0.0005451974,0.0001286889,0.0002894936],"domain_scores_gemma":[0.9994944,0.000009213301,0.00008115891,0.0002209567,0.00003681878,0.0001574873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002921877,0.0001717847,0.01694444,0.00001650616,0.00001657364,0.00001311539,0.0002665838,0.000001194392,0.9815626,0.000008566858,0.0001727665,0.0005336684],"study_design_scores_gemma":[0.001255841,0.0002459174,0.001457951,0.00001871148,0.000009857675,0.00002984544,0.0002115091,0.00004773922,0.9947329,0.00001823223,0.001706072,0.000265435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986081,0.0004781912,0.000007698847,0.0001412898,0.0001841071,0.0004244538,0.0001127842,0.00001257685,0.00003085357],"genre_scores_gemma":[0.9983817,0.000289226,0.0007254438,0.000140013,0.0001481965,0.000115924,0.0001376568,0.00002931972,0.00003252777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01548649,"threshold_uncertainty_score":0.8532629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005154890711083565,"score_gpt":0.2508460297787123,"score_spread":0.2456911390676288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}