{"id":"W1823812337","doi":"10.1593/neo.10296","title":"An Anti-Urokinase Plasminogen Activator Receptor Antibody (ATN-658) Blocks Prostate Cancer Invasion, Migration, Growth, and Experimental Skeletal Metastasis In Vitro and In Vivo","year":2010,"lang":"en","type":"article","venue":"Neoplasia","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Urokinase receptor; Metastasis; Cancer research; Biology; Protein kinase B; Prostate cancer; Pathology; Cancer; Medicine; Plasminogen activator; Signal transduction; Endocrinology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295233,0.0005923606,0.0004068142,0.0003116237,0.0001612331,0.0001725079,0.0003067723,0.0002203375,0.001235014],"category_scores_gemma":[0.00006497077,0.0002244795,0.0003760176,0.0002236421,0.0002423195,0.0001210837,0.0001465109,0.0009019906,0.0003453146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003032346,"about_ca_system_score_gemma":0.0004474054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002022547,"about_ca_topic_score_gemma":0.004878361,"domain_scores_codex":[0.9998116,0.0000316378,0.00001008743,0.00002515611,0.00005272461,0.00006881014],"domain_scores_gemma":[0.9999068,0.00001315643,0.00002579319,0.000008602368,0.000008537671,0.00003716133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001506092,0.0003150532,0.0001159156,0.00006530983,0.00001135572,0.00002704361,0.000009321783,0.0001043884,0.9970727,0.0000549402,0.0001045681,0.001968751],"study_design_scores_gemma":[0.00007519234,0.005560378,0.005105653,0.000009883239,0.00004763985,0.0002967651,0.00002003368,0.00115149,0.9853093,0.00002408507,0.002392255,0.000007389959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888191,0.005282718,0.002477263,0.000173609,0.00008110758,0.00007180396,0.0003731796,0.0002000863,0.002521124],"genre_scores_gemma":[0.9866664,0.004550919,0.002772261,0.00009388939,0.00002890975,0.0000946191,0.0009876211,0.00002354357,0.004781866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002022547,"threshold_uncertainty_score":0.004131496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005154890711083565,"score_gpt":0.2508460297787123,"score_spread":0.2456911390676288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}